Chiefs vs. Chargers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 3:22 p.m.

Moneyline (ML): Kansas City -275 (Bet $275 to win $100) | Los Angeles +220 (Bet $100 to win $220)Against the spread (ATS): Kansas City -5.5 (-110) | Los Angeles +5.5 (-110)Over/Under (O/U): 41.5 (O: -110 | U: -110)Chiefs vs. Chargers betting tips preview

The Kansas City Chiefs (6-7) and the Los Angeles Chargers (9-4) square off on Sunday, December 14, 2025 at GEHA Field at Arrowhead Stadium in a battle of AFC West foes, and here are best bets recommendations.

Last time out, the Chiefs took the loss against the Houston Texans, 20-10. The Chargers picked up a 22-19 win in their most recent outing, a matchup with the Eagles. Patrick Mahomes finished with 160 yards on 14-33 passing (42.4%) in the Chiefs’ last game while throwing three interceptions, plus seven rushing attempts for 59 yards. Kareem Hunt ran for one touchdown while compiling 30 yards on 12 attempts. Xavier Worthy earned 55 yards on three receptions.

In the Chargers’ last game, Justin Herbert threw for 139 yards on 12-26 passing (46.2%), throwing one touchdown and one interception, plus 10 rushing attempts for 66 yards. Omarion Hampton ran for 56 yards on 13 attempts.He also caught one touchdown pass. Kimani Vidal earned 60 yards on one reception.

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Chiefs vs. Chargers key injuriesChiefsWR Marquise Brown (NIR – Personal) did not participate in practiceS Bryan Cook (ankle) full participation in practiceTE Noah Gray (shoulder) full participation in practiceQB Patrick Mahomes (knee) full participation in practiceCB Trent McDuffie (knee) limited participation in practiceOL Wanya Morris (knee) did not participate in practiceWR Nikko Remigio (concussion) full participation in practiceWR Rashee Rice (hamstring) full participation in practiceOG Trey Smith (ankle) full participation in practiceWR JuJu Smith-Schuster (rib) full participation in practiceOT Jawaan Taylor (tricep) did not participate in practiceChargersWR Keenan Allen (rest) did not participate in practiceWR Derius Davis (ankle) did not participate in practiceTE Will Dissly (shoulder) limited participation in practiceLB Troy Dye (hip) did not participate in practiceQB Justin Herbert (hand) limited participation in practiceOLB Khalil Mack (rest) did not participate in practiceWR Ladd McConkey (foot) limited participation in practiceDB Elijah Molden (hamstring) did not participate in practiceOL Trey Pipkins (ankle) did not participate in practiceChiefs vs. Chargers prediction

Chiefs 24, Chargers 19

Moneyline pick: Chiefs -275The Chiefs have an implied moneyline win probability of 73.3% in this matchup.Kansas City has a 5-6 record in games they were listed as the moneyline favorite (winning 45.5% of those games).The Chiefs have won all three games they have played as a moneyline favorite with odds of -275 or shorter.Los Angeles has won both games it has played as underdogs this season.The Chargers have not entered a game this season with longer moneyline odds than +220.Pick ATS: Chargers (+5.5)Kansas City has a 5-8-0 record against the spread this season.The Chiefs have been favored by 5.5 points or more three times this season and have covered the spread in all of them.In 13 games played Los Angeles has recorded seven wins against the spread.Pick OU: Over (41.5)The Chiefs and their opponents have combined to score more than 41.5 points in seven of 13 games this season.Chargers games this season have had a combined scoring total higher than 41.5 points in seven of 13 outings.The teams combine to score 47.2 points per game, 5.7 more points than this matchup’s total.These two teams surrender a combined 40.2 points per game, 1.3 fewer points than this matchup’s over/under.

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