The San Francisco 49ers (9-4) are projected to keep their three-game winning streak going as they are heavily favored by 12.5 points against the Tennessee Titans (2-11) on Sunday, December 14, 2025 at Levi’s Stadium.

49ers vs. Titans game infoGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)

49ers vs. Titans odds & betting linesSpread favorite: San Francisco (-12.5)Moneyline: San Francisco (-935), Tennessee (+622)Total: 44.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

49ers vs. Titans recent matchupsTennessee and San Francisco have split their last two matchups (1-1).Tennessee outscored San Francisco 43-42 in the two head-to-head matchups between the two teams.49ers vs. Titans betting insightsSan Francisco, in 13 games with a spread this season, is 8-5-0 against the spread. In the nine games this season the 49ers have been favored on the moneyline, they have put up an 8-1 record. Tennessee is 6-7-0 against the spread through 13 opportunities this season. The Titans’ record when playing as the underdog this year is 2-11.49ers scoring insightsThe 49ers put up 20.6 points per game at home, which is lower than their 25.5 average away from home.On defense, San Francisco’s average at home, 20.4 points conceded, is a little lower than its average away, 20.9.The 49ers average more points in division games (25.2) than against the rest of the league (22.6).San Francisco is conceding 23.0 points per game in divisional matchups, which is higher than its 19.3 average versus the rest of the league.Over the last three games, the 49ers have been firing on all cylinders. During that three-game stretch, they rank fifth-best with 29.0 points per game and second-best on defense with 13.0 points allowed per contest.Titans scoring insightsAt home, the Titans’ scoring average is 16.0 points per game, which is higher than their average away (14.8).On defense, Tennessee’s average at home, 29.0 points conceded, is worse than its average away, 25.7.Offensively, the Titans average fewer points in division games (10.0) than against the rest of the league (18.9).Tennessee has given up 29.2 points per game in the division, which is worse than its mark against the rest of the league of 26.4.The Titans are putting up 19.3 points per game in their past three games (22nd in NFL), and giving up 28.0 per game (fifth-worst).49ers injury report49ers:
Trent Williams: Full Participation in Practice (NIR – Rest),
Kurtis Rourke: Full Participation in Practice (Knee),
Eddy Pineiro: Full Participation in Practice (Hamstring),
Sam Okuayinonu: Did Not Participate In Practice (Ankle),
Christian McCaffrey: Limited Participation in Practice (NIR – Rest),
Nickolas Martin: Did Not Participate In Practice (Concussion),
Kyle Juszczyk: Limited Participation in Practice (Ribs),
Kevin Givens: Full Participation in Practice (NIR – Personal),
Tatum Bethune: Did Not Participate In Practice (Ankle)Titans injury reportTitans:
Kevin Zeitler: Limited Participation in Practice (NIR – Rest),
James Williams: Did Not Participate In Practice (Illness),
Shy Tuttle: Full Participation in Practice (Concussion),
Jeffery Simmons: Full Participation in Practice (NIR – Rest),
C.J. Ravenell: Limited Participation in Practice (Toe),
Tony Pollard: Full Participation in Practice (NIR – Rest),
Chigoziem Okonkwo: Full Participation in Practice (NIR – Rest),
Dan Moore: Limited Participation in Practice (Neck),
Lloyd Cushenberry III: Limited Participation in Practice (Foot),
Jalyn Armour-Davis: Limited Participation in Practice (Achilles)

Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)