Week 15 of the 2025 NFL season rolls on with an AFC West matchup when the Los Angeles Chargers battle the Kansas City Chiefs on Sunday afternoon in the Show-Me State and we have you covered with our Chargers vs. Chiefs prediction. Los Angeles took down Philadelphia 22-19 in overtime at home in their previous game Monday night, winning outright as a one-point underdog. Kansas City fell 20-10 to Houston at home last Sunday night in their previous game, losing outright as a 4.5-point favorite. In the all-time regular season series between the teams, the Chiefs own a 71-58-1 advantage, but the Chargers took a 27-21 win as the “home” team in the first matchup this season, which took place in Sao Paolo, Brazil September 5. Read more about this Chargers vs. Chiefs prediction! Don’t get sacked this football season! Try our NFL Picks!
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Terms & Conditions Chargers Trying to Keep Pace in AFC West
Los Angeles won their second straight and their fifth in the last six games as they beat Philadelphia in overtime in a sloppy contest Monday night. The Chargers enter this game 9-4 on the year and stand second in the AFC West, two games behind the Broncos. They own the top wild-card spot in the AFC playoff picture. Against Philadelphia, Los Angeles led 7-3 after one quarter, 10-6 at the half and 13-9 after three quarters. The Chargers rallied twice from three-point deficits to tie the game, the second time on a Cameron Dicker 46-yard field goal with eight seconds remaining. In overtime, Los Angeles got a 54-yard field goal from Dicker and Tony Jefferson picked off Jalen Hurts on the ensuing possession to earn the win. The Chargers were beaten 365-275 in total offense and gave up 19 first downs while picking up 16 in the contest. Los Angeles did own a 38:05 to 29:26 margin in time of possession and forced five takeaways while committing three in the win.
On the year, the Chargers are 17th in the league in passing offense with 215.5 yards per game, while they are 9th in rushing offense with an average of 125.7 yards per contest. Los Angeles is 17th in the league in scoring offense with 23 points per contest and 9th in scoring defense by allowing an average of 20.8 points per contest. Justin Herbert has hit 277 of 422 passes for 2,981 yards with 22 touchdowns and 11 interceptions on the year. He has been sacked 45 times while ranking second on the team with 419 yards plus a score on the ground. Trey Lance is seven of 13 for 90 yards plus 16 rushing yards as the backup. Kimani Vidal leads the team with 135 carries for 587 yards and three scores on the ground. Omarion Hampton (79 carries, 370 yards, two TD), Jaret Patterson (32 carries, 129 yards) and Najee Harris (15 carries, 61 yards) are next in line. Ladd McConkey is second on the team with 59 receptions for 695 yards and five scores. Keenan Allen (63 receptions, 644 yards, four TD), Quentin Johnston (42 catches, 533 yards, seven TD), tight end Oronde Gadsden II (39 grabs, 551 yards, two TD) and Tre’ Harris (20 catches, 185 yards, TD) are solid secondary options in the passing game. Cameron Dicker is 28 of 28 on extra point attempts and 31 of 33 on field goal attempts with a long of 59 this season.
Key Injury Report for Chargers:
Wide receiver Derius Davis (ankle) is out. Defensive back Elijah Molden (hamstring) is doubtful. Guard/tackle Trey Pipkins III (ankle) is doubtful. Linebacker Troy Dye (hip) is questionable. Linebacker Khalil Mack (undisclosed) is questionable. Wide receiver Quentin Johnston (groin) is questionable. Kansas City Hoping to Stave Off Elimination
Kansas City dropped their second straight and fourth in the last five games as they were shut down at home by Houston last week. The Chiefs dropped to 6-7 on the year and stand third in the AFC East. They are 10th in the AFC playoff picture, two games behind the Texans for the final wild-card spot. All three teams occupying wild-card spots currently own tiebreakers over the Chiefs. Against Houston, Kansas City trailed 10-0 at the half, rallied to tie the game after three quarters and then was outscored 10-0 in the fourth quarter to wind up with the loss. The Chiefs held a narrow 274-268 edge in total offense and picked up 15 first downs while allowing 14 in the game. Kansas City lost time of possession by a 31:58 to 28:02 margin and turned the ball over three times while failing to record a takeaway.
The Chiefs enter this game 4th in the league in passing offense, as they average 248.2 yards per game this season. Kansas City is 17th in the league in rushing offense as they grind out 118.9 yards per contest on the ground. The Chiefs are 11th in scoring offense as they put up an average of 24.2 points per game, while they stand 7th in scoring defense as they allow 19.4 points per contest. Patrick Mahomes is the signal caller for the Chiefs: he is 299 of 474 for 3,398 yards with 22 touchdowns and 10 interceptions on the year. He is second on the team with 407 rushing yards plus four scores. Kareem Hunt is leading the team on the ground with 142 carries for 545 yards and eight scores on the season. Brashard Smith (30 carries, 94 yards) and Isiah Pacheco (90 carries, 375 yards, TD) are also in the mix. Travis Kelce is the team’s leading pass catcher with 60 receptions for 727 yards and five scores on the year. Xavier Worthy (38 catches, 456 yards, TD), Hollywood Brown (42 grabs, 494 yards, five TD), JuJu Smith-Schuster (27 catches, 304 yards, three TD), Smith (19 grabs, 171 yards), Rashee Rice (46 receptions, 520 yards, five TD) and Tyquan Thornton (17 catches, 391 yards, three TD) are other options. Harrison Butker is 29 of 33 on extra point attempts and 22 of 26 on field goal attempts with a long of 59 this season.
Key Injury Report for Chiefs:
Wide receiver Hollywood Brown (personal) is out. Tackle Wanya Morris (knee) is out. Tackle Jawaan Taylor (knee/triceps) is out. Guard Trey Smith (ankle) is out. Cornerback Trent McDuffie (knee) is questionable. Chargers vs. Chiefs PickSpread Pick for Chargers vs. Chiefs
Kansas City is getting by on its past reputation at this point. Sure, Arrowhead can be a tough place to play, but this is a Chiefs team that is off the rails. They’ve dropped four of their last five games straight up and are 0-5 against the number in that stretch. Mahomes and company were favored in each of those contests, but they’re without three offensive linemen, one of their top two receivers, and potentially their All-Pro corner. Los Angeles didn’t set the world on fire against the Eagles, but they got the win. The Bolts have also covered in seven of the last 10 meetings and won the first matchup this season. While we had to give Kansas City the benefit of the doubt earlier in the year, now they have to prove themselves similarly. Take the points in this contest.
Over/Under Pick for Chargers vs. Chiefs
Los Angeles has seen the under post a 7-6 mark in their 13 games in relation to the total this season. The Chargers split their six road games in relation to the total, though they have gone over the number in four of their last seven games overall. Kansas City enters this game having stayed under the number in nine of their 13 contests. The Chiefs have fallen under the number in seven of their last eight contests and have been held to 21 points or less in three of their last five contests. We’ve seen the under post a 3-1-1 mark in the last five meetings and that trend continues here. Take the under in this contest.
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