Expect some potential shakeups on the Tennessee Titans offensive line for the team’s Week 15 game against the San Francisco 49ers.

Titans interim coach Mike McCoy didn’t rule any linemen out for the Titans (2-11) game against the 49ers (9-4) at Levi’s Stadium on Dec. 14 (3:25 p.m. CT, FOX), but listed three starters as questionable: center Lloyd Cushenberry, guard Kevin Zeitler and tackle Dan Moore Jr.

This comes after a stretch of two weeks where the Titans played without Cushenberry III, who was replaced by Corey Levin.

Zeitler missed the Titans’ practices on Dec. 11 and 12, and was listed on the injury report with a groin injury. Cushenberry and Moore both sustained injuries back on Nov. 30 against Jacksonville, though Moore was able to play through his in Week 14.

With Blake Hance, Zeitler’s backup early in the year, on injured reserve, the options for how the Titans will handle Zeitler’s absence depend on Cushenberry’s and Levin’s statuses. Cushenberry practiced all week, but the offense moved well with Levin at center in Week 14 against Cleveland, putting together a season-high rushing total.

Levin could bump out to guard if Cushenberry plays center, but if Cushenberry isn’t ready or the Titans prefer to stick with Levin, the other options would include rookies Jackson Slater and Drew Moss.

“I think it’s been good, I’m just working my way back in,” Cushenberry said of his week of preparation. “I’m pushing my way through some discomfort still, but I’ll be good to go.”

Cushenberry spoke positively about how the Titans ran the ball in his absence, the dedication to keep pounding the run and of Levin’s performance broadly. Speaking about his own struggles in his two seasons with the Titans, Cushenberry said he’s not really sure how to sum up why he’s been inconsistent. He said he feels he’s working hard enough, but he just hasn’t been good enough. That said, Cushenberry believes “the tide is going to turn” soon.

Slater, the Titans’ fifth-round pick in 2025, has only played on special teams thus far. Moss, an undrafted rookie who spent time with San Francisco before arriving in Nashville, has also yet to play an offensive snap.

Talking about Slater’s progress as a rookie out of an FCS school, McCoy referenced the value of Slater having to line up every day in practice against All-Pro defensive tackle Jeffery Simmons. Slater told The Tennessean he sees the value in those reps, as well as the reps he’s taken when Zeitler misses practice for his weekly veteran rest days.

“Initially, it felt like I kind of made a mountain out of a molehill a little bit where it was like ‘There’s all this stuff going on and I don’t really understand it and we didn’t run all this stuff,'” Slater said. “OTAs and maybe early on in training camp it was a little rough. But once you kind of get into a groove and you start to understand concepts and understand techniques and how you’re supposed to play, I think it’s come along really well.”

The 49ers’ defensive front hasn’t lived up to its usually-harrowing reputation in 2025. San Francisco ranks last in the NFL in total sacks, pressure rate and sack rate, and ranks bottom six in the league in both quarterback hits and tackles for loss.

Titans injury report vs 49ers

Ruled OUT: CB Jalyn Armour-Davis

Ruled QUESTIONABLE: LT Dan Moore Jr., RG Kevin Zeitler, OC Lloyd Cushenberry III, DT C.J. Ravenell, ILB James Williams Sr.

Nick Suss is the Titans beat writer for The Tennessean. Contact Nick at  nsuss@gannett.com. Follow Nick on X @nicksuss. Subscribe to the Talkin’ Titans newsletter for updates sent directly to your inbox.