Take a look at the injury report for the San Francisco 49ers (9-4), which currently has 10 players listed (including Christian McCaffrey), as the 49ers ready for their matchup versus the Tennessee Titans (2-11) at Levi’s Stadium, on Sunday, Dec. 14 at 4:25 p.m. ET.
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49ers vs Titans TV channel & game infoGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
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49ers injury reportKurtis Rourke | QB (Out)Injury: KneePractice Status: Full Participation in PracticeSam Okuayinonu | DL (Out)Injury: AnklePractice Status: Did Not Participate In Practice2025 Defensive Stats: 2.0 Sacks | 3.0 Tackles for Loss | 31 Tackles | 0 Interceptions | 0 Passes DefendedNickolas Martin | LB (Out)Injury: ConcussionPractice Status: Did Not Participate In PracticeTatum Bethune | LB (Out)Injury: AnklePractice Status: Did Not Participate In Practice2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 64 Tackles | 0 Interceptions | 1 Pass DefendedYetur Gross-Matos | DL (Out)Injury: HamstringPractice Status: Limited Participation in PracticeChristian McCaffrey | RB (Questionable)Injury: NIR – RestPractice Status: Full Participation in Practice2025 Rushing: 237 Attempts | 849 Yards | 8 Touchdowns2025 Receiving Stats: 107 Targets | 85 Receptions | 806 Yards | 5 TouchdownsTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2025 Season Stats: 5 Games PlayedEddy Pineiro | KInjury: HamstringPractice Status: Full Participation in Practice2025 Season Stats: 10 Games PlayedKyle Juszczyk | FBInjury: RibsPractice Status: Full Participation in Practice2025 Season Stats: 13 Games PlayedKevin Givens | DLInjury: NIR – PersonalPractice Status: Full Participation in Practice49ers insightsThe 49ers have scored more points per game over their previous three matchups (29.0) than they have averaged for the season (23.6).Turning our focus to yardage, San Francisco is compiling 341.2 total yards per game this season, but it has been worse over its last three matchups, averaging 291.0 yards per contest.In the passing game, the 49ers have seen a dip in production over their last three games, racking up 180.0 passing yards per game, compared to their season-long average of 242.6 passing yards per contest.San Francisco has racked up more rushing yards per game over its previous three matchups (111.0) than it has averaged for the season (98.5).49ers vs Titans odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 5:30 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-12.5)Moneyline: 49ers (-877), Titans (+592)Total: 44.5 points
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