San Francisco (9-4) rides a three-game winning streak into a matchup with Tennessee (2-11) on Sunday, December 14, 2025 at Levi’s Stadium. The 49ers are notable favorites in this one, with the spread posted at 12.5 points. The over/under for the contest is 44.5 points.
The Titans‘ most recent contest was against the Cleveland Browns, and they won by a score of 31-29.
Against the Browns, Cameron Ward completed 14 of 28 attempts for 117 yards, with two touchdowns and one interception, for the Titans.
The 49ers beat the Cleveland Browns, 26-8, in their most recent game.
Titans vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 9:15 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-12.5)Moneyline: San Francisco (-877), Tennessee (+592)Total: 44.5 pointsTitans betting insightsTennessee is 2-4 overall, and 3-3 against the spread, in away games.The Titans have compiled a 6-7-0 record against the spread this season.Tennessee is winless ATS (0-1) as 12.5-point underdogs or more on the road.The Titans have an ATS record of 1-1 when playing as at least 12.5-point underdogs.In three of six road games this year, Tennessee has gone over the total.Games involving Titans have hit the over eight times this year.Titans leadersWard: 2,468 PASS YDS / 189.8 YPG / 59.1% / 9 TD / 7 INTTony Pollard: 175 CAR / 743 YDS / 57.2 YPG / 4 TD / 27 REC / 171 YDS / 13.2 YPG / 0 TDTyjae Spears: 47 CAR / 177 YDS / 19.7 YPG / 1 TD / 30 REC / 201 YDS / 22.3 YPG / 0 TDChigoziem Okonkwo: 41 REC / 426 YDS / 32.8 YPG / 0 TDElic Ayomanor: 30 REC / 353 YDS / 29.4 YPG / 3 TDGunnar Helm: 37 REC / 298 YDS / 22.9 YPG / 1 TDTitans vs 49ers game infoDate: Sunday, December 14, 2025Time: 4:25 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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