Our computer prediction calls for a narrow win (22-19) for the Carolina Panthers (7-6) over the New Orleans Saints (3-10) on Sunday, Dec. 14 at Caesars Superdome (kickoff at 4:25 p.m. ET).
Panthers vs. Saints predictionsPick ATS: Saints (+2.5)Pick OU: Over (40.5)Prediction:
Panthers 22 – Saints 19Panthers vs. Saints odds and lines
National Football League odds courtesy of BetMGM. Odds updated Saturday at 11:34 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Panthers (-2.5)Moneyline: Panthers (-155), Saints (+130)Total: 40.5 pointsPanthers betting statsCarolina’s record against the spread is 8-5-0.The Panthers are winless ATS (0-1) when playing as at least 2.5-point favorites this year.This season, seven of Carolina’s 13 games have hit the over.Saints betting statsNew Orleans is 5-8-0 against the spread this year.The Saints are 4-7 as 2.5-point underdogs or greater.New Orleans has seen four of its 13 games go over the point total.The Saints have entered the game as underdogs 11 times this season and won twice.Panthers vs. Saints game infoGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: New Orleans, LouisianaStadium: Caesars SuperdomeTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Carolina Panthers vs. New Orleans Saints on Fubo! (Regional restrictions may apply)