One of the best receivers in the league will be on show when Christian McCaffrey and the San Francisco 49ers (9-4) host the Tennessee Titans (2-11) on Sunday, December 14, 2025.
The 49ers are averaging 23.6 points per game on offense (16th in NFL), and they rank eighth on defense with 20.7 points allowed per game. The Titans have been outplayed on both sides of the ball this season, ranking second-worst in points (15.5 per game) and fourth-worst in points allowed (27.5 per game).
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
49ers vs Titans: live streaming info, TV channel & game timeGame day: Sunday, December 14, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
49ers vs Titans betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-12.5)Moneyline: 49ers (-877), Titans (+592)Total: 44.5 points
Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)