The Indianapolis Colts (8-5) and Seattle Seahawks (10-3) meet in a battle with playoff implications Sunday. Kickoff from Seattle, Washington, is set for 4:25 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Colts vs. Seahawks odds and make our expert NFL picks and predictions for the best bets.

Indianapolis was routed 36-19 by the Jacksonville Jaguars in Week 14 while failing to cover as a 2.5-point road favorite as the Over (45) cashed. QB Daniel Jones suffered a season-ending injury in the loss, and while Indy has not named an official starter, all signs are pointing to former Colts star QB Philip Rivers, who retired in 2021 and is 44 years old, starting. The Colts have lost 3 straight and have failed to score over 20 in any of those losses.

Seattle dominated the Atlanta Falcons 37-9 Sunday to cover as a 6.5-point road favorite as the Over (44) hit. The Seahawks forced 3 turnovers while holding the Falcons to just 1-of-13 on 3rd down and 0-for-4 in the red zone. Rashid Shaheed returned the opening second-half kickoff for a TD to spark a 31-3 domination in the final half for the Seahawks.

Seattle won the last meeting 28-16 in 2021, but the Colts lead the all-time series 7-6.

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Colts vs. Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:23 p.m. ET.

Moneyline (ML): Colts +625 (bet $100 to win $625) | Seahawks -900 (bet $900 to win $100)Against the spread (ATS): Colts +14 (-120) | Seahawks -14 (-110)Over/Under (O/U): 42.5 (O: -110 | U: -110)Colts at Seahawks key injuries

Colts

DT DeForest Buckner (neck) outCB Sauce Gardner (calf) outWR Anthony Gould (foot) outOT Braden Smith (concussion/neck) out

Seahawks

C Jalen Sundell (knee) questionableColts at Seahawks picks and predictionsPrediction

Seahawks 27, Colts 11

PASS.

With so much uncertainty at QB and the Seahawks having so much more momentum than this reeling Colts team, look for the Seahawks to comfortably win to cover here as -900 favorites. However, no team favored so heavily is worth the risk of betting on, so pass and bet on the spread and/or total instead.

LEAN SEAHAWKS -14 (-110).

Seattle’s defense is top-4 in sacks per game, rushing yards per game, and points per game. Furthermore, the Seahawks are one of the best teams at forcing turnovers, sitting at sixth in turnovers forced on the season (21). On the other side, these squads match up extremely well against one another, so it will be the defense that makes all the difference here.

This is a slight lean because Indianapolis has a very good run defense while also being very good at protecting the ball.

BET UNDER 43 (-110).

With both defenses being some of the best in the league against the run, offense will be hard to find consistently for both teams. Furthermore, look for the pass rush of Seattle to cause a lot of problems and make passing the ball down the field just as hard for the Colts. Oh, and did we mention that Rivers hasn’t thrown a pass in the NFL since 2021?

The Under has hit in 2 of the Colts’ last 3 games, while also hitting in the most recent matchup between these squads.

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