Arizona (3-10) brings a five-game losing streak into a matchup with Houston (8-5) on Sunday, December 14, 2025 at NRG Stadium. The Texans are undoubtedly the favorites in this one, with the line sitting at 10.5 points. An over/under of 42.5 points has been set for the outing.

Last time out, the Texans defeated the Kansas City Chiefs, with 20-10 being the final score.

The Texans’ C.J. Stroud went 15-for-31 for 203 yards versus the Chiefs, with one TD and no INTs.

The Cardinals lost versus the Los Angeles Rams in their last game, 45-17.

Texans vs Cardinals betting information

NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:04 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread favorite: Houston (-10.5)Moneyline: Houston (-578), Arizona (+431)Total: 42.5 pointsTexans betting insightsHouston is 4-2 against the spread, and 4-2 overall, at home.The Texans have covered the spread in a matchup seven times this season (7-6-0).In six home games this season, Houston has hit the over once.Texans games have gone over the total three times this season.Texans leadersStroud: 2,181 PASS YDS / 218.1 YPG / 64.3% / 12 TD / 6 INT / 32 CAR / 194 RUSH YDS / 0 TDWoody Marks: 160 CAR / 554 YDS / 42.6 YPG / 2 TD / 20 REC / 196 YDS / 15.1 YPG / 3 TDNick Chubb: 115 CAR / 472 YDS / 36.3 YPG / 3 TD / 12 REC / 58 YDS / 4.5 YPG / 0 TDNico Collins: 61 REC / 916 YDS / 76.3 YPG / 4 TDDalton Schultz: 62 REC / 574 YDS / 44.2 YPG / 1 TDJayden Higgins: 35 REC / 393 YDS / 30.2 YPG / 4 TDTexans vs Cardinals game infoDate: Sunday, December 14, 2025Time: 1 p.m. ETCity: Houston, TexasVenue: NRG StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)

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