When the New England Patriots traveled into Highmark Stadium and knocked off the Buffalo Bills in a 23-20 Week 5 victory, it sent a warning call to the rest of the NFL that the Patriots are back. Now 10 weeks later the Bills are in town seeking revenge.

New England is one of the hottest teams in the NFL with 10 straight wins this season, but the Bills are trending at the right time having won three of their last four games.

Those looking to wager on the game have countless options on where and what to wager. The top Massachusetts sportsbooks will be offering an assortment of odds and markets available for this AFC East showdown. I’ve taken the time to research and gather the best value on some of the most popular props.

The oddsmakers favor Buffalo ahead of kickoff as the Bills are one to 1.5-point favorites across the top sportsbooks on the market. The over/under for the game is currently being offered at 49.5 points.

Bills vs. Patriots PredictionPatriots Over 24.5 Points: -105 at DraftKingsJosh Allen Over 225.5 Passing Yards: -115 at FanaticsDrake Maye Over 4.5 Rushing Attempts: -118 at BetMGM

Note: Odds are based on the best value our experts find as of publication; check lines closer to game time to ensure you get the best odds.

The New England Patriots have put up 25 or more points in seven of the last eight games played. The Bills have also allowed their opponents to produce 25 or more points in five of their previous seven games. With the Patriots’ offensive efficiency as of late, I like them to outproduce this line.

That won’t come without some pushback from the Bills’ offense, as Josh Allen enters this game coming off his best game all season. The eight-year veteran has gone over 226 passing yards in five of his last six games and had 253 yards against New England earlier this year.

Drake Maye has been stellar through the air this season, but his legs have been an underrated aspect of his game. The second-year quarterback has gone over this line in seven of his last eight games played and should do so again this Sunday. He only ran three times against Buffalo in Week 5, but the team’s passing attack wasn’t as proven then; things should change this time around.

Bills vs. Patriots moneyline odds analysisWhy Bills could win as the favorite

Best odds: -118 at FanDuel

The Bills are the projected favorite across the board in this matchup for all major sportsbooks. DraftKings Sportsbook gives Buffalo the best chance of victory, offering a moneyline of -120, with FanDuel offering the best value to bettors at -118.

Buffalo enters this game with a chip on its shoulder after the Patriots beat them in Week 5 in a stunning loss at home. The chance for revenge will be plenty of motivation, but the team is also at risk of losing its five-year streak as AFC East champions with a loss today.

When Josh Allen runs your offense, you feel good heading into every game. The star quarterback is coming off a four-touchdown game against the Cincinnati Bengals to pull out a 39-34 victory. The team will need to remain hot offensively in Week 15 to match the Drake Maye-led Patriots.

The defense has been less consistent this season, but the team has forced interceptions in six of the last seven games played. New England’s only two losses this season came in games with interceptions thrown, so the Buffalo secondary will need to create some chaos to help knock off New England in Foxborough.

Why Patriots could win as the underdog

Best odds: +100 at BetMGM

Oddsmakers across the top sportsbooks view the Patriots as underdogs; in fact, each platform is currently offering the same +100 moneyline.

The Patriots have been on fire as of late, with 10 straight victories and efficient offensive play. The team averages 27 points per game this season, ranking eighth in third-down attempts and putting them in favorable situations to score.

As good as the offense has been, the defense has also come together well in New England. The unit allows the fewest points per game (18.5), and that total drops when at home (17.0). They held Buffalo to 20 in Week 5; the team will be in a good position to win if they can put forward a similar result today.

New England enters this game with a chance to clinch the AFC East for the first time since 2019. The team is young and hungry to prove itself, so there will be no lack of motivation in this game.

The team handled business against Buffalo on the road in Week 5 and gets home-field advantage in a rematch 10 weeks later. Things are never steady in the NFL, but the Patriots have to like their chances more than oddsmakers currently do.

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