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NFL Week 15 overreactions

USA TODAY’s Prince Grimes breaks down the best storylines from NFL Week 15.

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The Los Angeles Chargers and Dallas Cowboys play on Sunday, Dec. 21, at the Cowboys’ AT&T Stadium in a game on the NFL Week 16 schedule.

Which team will win the NFL Week 16 game?

Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 11 a.m. MST on FOX (stream with FUBO).

The Cowboys are a 1.5-point favorite over the Chargers in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.

Dallas is -118 on the moneyline, while Los Angeles is -102. The over/under (point total) is set at 49.5 points.

NFL Week 16 picks: Rams at Seahawks | Eagles at Commanders | Packers at Bears | Buccaneers at Panthers | Bills at Browns | Chargers at Cowboys | Jets at Saints | Vikings at Giants | Chiefs at Titans | Bengals at Dolphins | Falcons at Cardinals | Jaguars at Broncos | Steelers at Lions | Raiders at Texans | Patriots at Ravens | 49ers at Colts | The Republic’s score predictions

Watch Chargers at Cowboys live on FUBO (free trial)

Jeremy Cluff writes: “The Chargers don’t win pretty. They don’t usually win big. But they just win, to the tune of a 10-4 record. Justin Herbert and company will make it four straight wins with a Week 16 victory in Dallas.”

Bookies.com: Bet the Chargers with the points vs Cowboys

Bill Speros writes: “The Chargers officially eliminated Patrick Mahomes and the Chiefs Sunday with a 16-13 victory. The Bolts’ defense held KC just 13 points before Mahomes left the game with a torn ACL. That same defense tees up against the Cowboys this week. After their loss to Minnesota Sunday night, the Cowboys have a 1% chance to make the playoffs. That number moves to 0% this week as the Bolts electrify Jerry World on both sides of the ball. This one may be worth a peek in the 4th quarter as the FOX cameras turn to Jerry Jones’ luxury suite as the Cowboys’ Super Bowl drought officially turns 30. The Chargers have covered in 8 straight as road dogs against NFC teams.”

The site’s formula predicts that the Chargers will win the NFL Week 16 game against the Cowboys.

ESPN: Chargers have a 51.5% chance to beat Cowboys on Sunday

The site gives the Cowboys a 48.1% shot at winning the NFL Week 16 game, with the remaining percentage accounting for a tie.

Dimers: Cowboys 25, Chargers 23

It writes: “After extensive simulations, our model gives the Chargers a win probability of 43%, while the Cowboys have a win probability of 57%.”

Sportsnaut: Los Angeles Chargers 23, Dallas Cowboys 20

Matt Johnson writes: “These are two very flawed football teams, with glaring issues that will be tested at the same time in Week 16. Over the last six games, the Los Angeles Chargers offensive line has surrendered 28 sacks (4.7 sacks per game) and the highest pressure rate in the NFL. The good news for the Dallas Cowboys is that their five-man front can take full advantage of that. However, when Justin Herbert has time to throw, he’ll get to attack a Cowboys secondary that has allowed a 68.7 percent completion rate, 110.5 QB rating, 8.2 yards per attempt, with 267 passing yards and 2 passing touchdowns per game over the last month. It’s because of that secondary and Los Angeles being far better coached defensively that we think the Chargers win and improve to 11-4.”

NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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