The Buffalo Bills are set to travel to Cleveland to face the eliminated Browns in a critical Week 16 matchup that is essential for keeping their AFC East title hopes alive and solidifying their Wild Card position.

The Bills’ preparation has been immediately undermined by special teams chaos. Head coach Sean McDermott confirmed the team will be without veteran kicker Matt Prater (right quad), who joins Tyler Bass (out for the season) on the sidelines, forcing Buffalo to sign an emergency kicker.

“Not ideal. Matt’s done a really good job having that consistency during the year,” McDermott said, highlighting the serious issue this presents in a must-win game.

The Bills also lose defensive tackle Jordan Phillips (ankle). However, there is balancing good news: cornerback Christian Benford and linebacker Terrel Bernard are “improving,” and the return window for wide receiver Mecole Hardman may open this week.

This mix of critical absences (kicker, DT) and key defensive returns prompted analysts to urgently reevaluate Bills vs. Browns predictions. New simulations now heavily focus on special teams vulnerability versus the potential boost in defensive play.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Browns preview below.

Bills vs. Browns betting preview

Explore the interactive widget below to discover the current spread, total, and moneyline odds and probabilities for the Bills-Browns matchup at Huntington Bank Field.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Browns is from Dimers.com, a dependable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Bills vs. Browns NFL game.

Teams: Buffalo Bills vs. Cleveland BrownsDate: Sunday, December 21, 2025Kickoff: 1 p.m. ESTLocation: Huntington Bank FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL contest between the Bills and Browns.

Spread: Bills -8.5 (-110), Browns +8.5 (-110)Moneyline: Bills -485, Browns +385Total: Over/Under 42.5 (-110/-110)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Bills vs. Browns

Leveraging advanced data analysis and computer power, the experts at Dimers have performed 10,000 simulations of Sunday’s Bills vs. Browns matchup.

According to Dimers’ popular predictive analytics model, the Bills are more likely to beat the Browns at Huntington Bank Field. This prediction is based on the model giving the Bills an 80% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and the Bills and Browns each have a 50% chance of covering the spread, while the over/under total of 42.5 points has a 54% chance of staying under.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Bills vs. Browns best bet

Our top pick for the Bills vs. Browns Week 16 NFL game is to bet on Under 42.5 points (-110).

This betting advice is formulated through world-class simulations and valuable betting intelligence, designed to bring you the best possible plays.

Score prediction for Bills vs. Browns

Dimers’ projected final score for the Buffalo vs. Cleveland game on Sunday has the Bills winning 25-16.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: SundayNFL Week 16: Bills vs. Browns

Get ready for Sunday’s matchup between the Bills and Browns in Week 16 of the National Football League season at Huntington Bank Field, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Bills vs. Browns matchup, and they are correct at the time of publishing to help you make better decisions when placing bets at online sportsbooks.

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