NFL Week 15 overreactions
USA TODAY’s Prince Grimes breaks down the best storylines from NFL Week 15.
Sports Seriously
The Buffalo Bills and Cleveland Browns play on Sunday, Dec. 21, at the Browns’ Huntington Bank Field in a game on the NFL Week 16 schedule.
Which team will win the NFL Week 16 game?
Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 11 a.m. MST on CBS (stream with FUBO).
The Bills are a 10-point favorite over the Browns in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.
Buffalo is -600 on the moneyline, while Cleveland is +425. The over/under (point total) is set at 42.5 points.
NFL Week 16 picks: Rams at Seahawks | Eagles at Commanders | Packers at Bears | Buccaneers at Panthers | Bills at Browns | Chargers at Cowboys | Jets at Saints | Vikings at Giants | Chiefs at Titans | Bengals at Dolphins | Falcons at Cardinals | Jaguars at Broncos | Steelers at Lions | Raiders at Texans | Patriots at Ravens | 49ers at Colts | The Republic’s score predictions
Watch Bills at Browns live on FUBO (free trial)
Jeremy Cluff writes: “Will Buffalo have a letdown after its huge win over New England? We don’t think so. Josh Allen and the Bills still have a shot at the AFC East title. They will be too much for Shedeur Sanders and the Browns.”
Bookies.com: Bet the Bills to cover vs Browns
Bill Speros writes: “The Bills put themselves in the middle of the Super Bowl 60 conversation in Week 15 with a thrilling come-from-behind 35-31 win over the Patriots at Gillette Stadium. The Bills trailed 21-0 and 24-7 at the half before scoring on 5 straight possessions. Buffalo’s offensive line dominated the line of scrimmage and Josh Allen was pin-point perfect. The Browns, long since eliminated, remain in the chase for the No. 1 overall pick. They tapped out in a 31-3 loss to Chicago Sunday. Look for lots of James Cook early, and lots of scrubs in the second half. Buffalo may only need 21 points to secure this cover.”
The site’s formula predicts that the Bills will win the NFL Week 16 game against the Browns.
ESPN: Bills have an 80.6% chance to beat Browns on Sunday
The site gives the Browns a 19.3% shot at winning the NFL Week 16 game, with the remaining percentage accounting for a tie.
Dimers: Bills 25, Browns 17
It writes: “After extensive simulations, our model gives the Bills a win probability of 80%, while the Browns have a win probability of 20%.”
Sportsnaut: Buffalo Bills, Cleveland Browns 13
Matt Johnson writes: “At one point in the season, this could’ve been a matchup where the Cleveland Browns shocked the NFL world and pulled off the upset. That’s no longer the case. Cleveland has now allowed 137.9 rushing yards per game with a 4.4 yards-per-carry average in the last seven weeks. So, for the Buffalo Bills, the game plan is simply to let Josh Allen and James Cook run wild in the cold. Buffalo will take an early lead on Sunday and force the Browns to play from behind. That’s not a favorable scenario for Shedeur Sanders, especially behind this offensive line against a top-10 pass defense.”
NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don’t miss a thing.