For Monday’s game, which kicks off at 8:15 p.m. ET on ESPN, oddsmakers have installed player prop bet markets on Christian McCaffrey. The San Francisco 49ers (10-4) and McCaffrey face off versus the Indianapolis Colts (8-6) in a Week 16 matchup from Lucas Oil Stadium in Indianapolis, Indiana.
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Christian McCaffrey week 16 player propsMatchup: San Francisco 49ers at Indianapolis ColtsTime: 8:15 p.m. ETDate: December 22, 2025Rushing yards prop: Over 65.5 (-115)Receiving yards prop: Over 35.5 (-118)
National Football League odds courtesy of BetMGM. Odds updated Tuesday at 9:51 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Christian McCaffrey rushing stats and trendsMcCaffrey rushes for 65.9 yards per game this season, which outpaces Monday’s prop total of 65.5 yards.He has totaled over 65.5 yards on the ground in six of 14 games so far this season.McCaffrey has come up short of his season-long rushing yards prop average (68.0) by 2.1 yards per game.McCaffrey has hit his rushing yards over in six of 14 opportunities (42.9% of his opportunities).He scored a rushing TD in seven games this year, with multiple rushing touchdowns two times.49ers vs. Colts stats and trendsConceding 95.1 rushing yards per game, the Colts have the fifth-ranked run defense in the league.The Colts have the NFL’s 31st-ranked pass defense this season, giving up 247.6 yards per game through the air.The 49ers rank 22nd in pass defense this year (227.6 passing yards allowed per game), but they’ve been thriving on the offensive side of the ball, ranking fourth-best in the NFL with 246.1 passing yards per game.The 49ers are compiling 101.4 rushing yards per game on offense, which ranks them 25th in the NFL. Defensively, they rank 12th, surrendering 106.1 rushing yards per game.The 49ers are putting up 5.5 yards per play on offense, which ranks them 15th in the NFL. Defensively, they rank 19th, giving up 5.7 yards per play.
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