Check out these betting insights before placing player prop wagers on Brock Purdy for Monday’s game, which starts at 8:15 p.m. ET on ESPN. This Week 16 matchup features Purdy’s San Francisco 49ers (10-4) taking on the Indianapolis Colts (8-6) at Lucas Oil Stadium in Indianapolis, Indiana.
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Brock Purdy week 16 player propsMatchup: San Francisco 49ers at Indianapolis ColtsTime: 8:15 p.m. ETDate: December 22, 2025Passing yards prop: Over 244.5 (-115)Rushing yards prop: Over 9.5 (-118)
National Football League odds courtesy of BetMGM. Odds updated Tuesday at 9:53 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Brock Purdy passing stats and trendsPurdy’s passing yardage average this year (240.3) is 4.2 below Monday’s over/under.He has exceeded 244.5 pass yards three times across six games played this season.Purdy’s passing yards average (240.3) is higher than his average prop total this year (240.0) by 0.3 yards.Purdy has surpassed his passing yards prop total in three of six opportunities this year.He has a passing touchdown in all six games this season, with multiple passing TDs in four of them.In three of six games this year, Purdy has thrown an interception, with more than one pick on three occasions.49ers vs. Colts stats and trendsThe Colts have the NFL’s 31st-ranked pass defense this season, allowing 247.6 yards per game through the air.Offensively, the 49ers have been a top-five unit in terms of passing yards, ranking fourth-best in the NFL by putting up 246.1 per game. They rank 22nd on defense (227.6 passing yards allowed per game).The 49ers are putting up 101.4 rushing yards per game on offense (25th in the NFL), and they rank 12th on defense with 106.1 rushing yards allowed per game.The 49ers are allowing 5.7 yards per play on the defensive side of the ball (19th in the NFL), while gaining 5.5 per play (15th in the league) on offense this season.
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