The Atlanta Falcons (5-9) visit the Arizona Cardinals (3-11) at State Farm Stadium in Glendale for a Week 16 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, December 21, including live updated odds and injury report news.
NameWeek 152025 SeasonBlake Schuster7-9115-91-5Jon Hoefling5-11109-110-5Tyler Dragon10-6110-109-5Chris Bumbaca10-693-97-4Lorenzo Reyes10-6107-112-5Jordan Mendoza8-887-103-4Richard MorinN/A37-29-2Cardinals vs. Falcons live odds, moneyline, over/under
Opening Lines
Spread: Cardinals (-3.5)Moneyline: Cardinals (-185), Falcons (+154)Over/Under: 46.5
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Cardinals vs. Falcons picks against the spreadTyler Dragon: Atlanta Falcons (-2.5)
Bijan Robinson is the difference in this game. Plus, Atlanta’s defense is quietly playing better.
Jon Hoefling: Atlanta Falcons (-2.5)
This one is tough, but I’ll take the team that hasn’t lost to the Tennessee Titans this year.
Jordan Mendoza: Atlanta Falcons (-2.5)
Arizona’s defense is going to have its hands full trying to contain Bijan Robinson. The Falcons get another win to help the confidence meter.
Blake Schuster: Atlanta Falcons (-2.5)
Based on how the Cardinals look, Arizona hit that “sim to offseason” button on Thanksgiving.
Christopher Bumbaca: Atlanta Falcons (-2.5)
The Falcons are the better-rested squad and I like the defense’s matchup against Jacoby Brissett. Maybe Atlanta’s offense has unlocked something, too?
Richard Morin: Atlanta Falcons (-2.5)
Kirk Cousins had his best performance in relief of Michael Penix Jr. in a Week 15 win over the Buccaneers. The Cardinals, meanwhile, are running out of steam this season.
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