The Jacksonville Jaguars (10-4) visit the Denver Broncos (12-2) at Empower Field at Mile High in Denver for a Week 16 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, December 21, including live updated odds and injury report news.

NameWeek 152025 SeasonBlake Schuster7-9115-91-5Jon Hoefling5-11109-110-5Tyler Dragon10-6110-109-5Chris Bumbaca10-693-97-4Lorenzo Reyes10-6107-112-5Jordan Mendoza8-887-103-4Richard MorinN/A37-29-2Broncos vs. Jaguars live odds, moneyline, over/under

Opening Lines

Spread: Broncos (-5.5)Moneyline: Broncos (-245), Jaguars (+200)Over/Under: 45.5

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Broncos vs. Jaguars picks against the spreadTyler Dragon: Denver Broncos (-3)

Will Denver’s 11-game winning streak end soon? This is a big test for both teams. The Broncos just seem to find ways to win.

Jon Hoefling: Jacksonville Jaguars (+3)

Denver has been flying a little too close to the sun recently. Going up against a very hot Jacksonville squad will bring the Broncos back down to Earth a bit before the postseason.

Jordan Mendoza: Denver Broncos (-3)

Two of the hottest teams in the AFC. Denver showed against Green Bay how tough it is to play the Broncos in the Mile High city. Jacksonville will likely learn the same lesson.

Blake Schuster: Jacksonville Jaguars (+3)

I know what we’re all thinking, but the forecast calls for an unseasonably warm day in Denver. This might end up being a nice upset spot for the Jags.

Christopher Bumbaca: Denver Broncos (-3)

I keep saying the Broncos’ streak has to end at some point. Maybe it doesn’t? I don’t see the Jags replicating their recent success in Mile High.

Richard Morin: Jacksonville Jaguars (+3)

Trevor Lawrence is brimming with confidence and the Jaguars are clinging to the AFC South lead. It feels like the Broncos need to lose again at some point.

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