The Seattle Seahawks find themselves in a precarious position for their most high-stakes home game in recent memory as they host the Los Angeles Rams on Thursday Night Football. With the NFC West lead and the conference’s No. 1 seed hanging in the balance, Seattle must protect its home turf without the anchor of its offensive line.

The Seahawks have officially ruled out starting left tackle Charles Cross due to a hamstring injury sustained late in their Week 15 victory. Cross, the primary protector for quarterback Sam Darnold, was unable to practice on the short week, leaving a massive void on the blindside just as the playoff race reaches a fever pitch.

Coach Mike Macdonald confirmed that backup Josh Jones will make his first start since 2023. Macdonald expressed confidence in Jones’ preparation, noting his solid performance during similar preseason opportunities.

On the other side, the Rams are dealing with their own major uncertainty as star wideout Davante Adams is listed as doubtful. These critical absences on both sides have triggered an immediate reevaluation of the betting landscape. Dimers’ analysts have run fresh simulations to determine how Seattle’s reshuffled front will hold up in this primetime title fight.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Rams-Seahawks preview below.

Rams vs. Seahawks betting preview

Explore the interactive widget below to discover the latest spread, total, and moneyline odds and probabilities for the Rams-Seahawks game at Lumen Field.

This prediction and best bet for Thursday’s NFL matchup between the Rams and Seahawks is from Dimers.com, a dependable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Rams vs. Seahawks NFL game.

Teams: Los Angeles Rams vs. Seattle SeahawksDate: Thursday, December 18, 2025Kickoff: 8:15 p.m. ESTLocation: Lumen FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Rams-Seahawks NFL contest.

Spread: Rams +1.5 (-108), Seahawks -1.5 (-102)Moneyline: Rams +110, Seahawks -120Total: Over/Under 42.5 (-105/-110)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Rams vs. Seahawks

Utilizing trusted data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Thursday’s Rams vs. Seahawks game.

According to Dimers’ independent predictive analytics model, the Seahawks are more likely to beat the Rams at Lumen Field. This prediction is based on the model giving the Seahawks a 55% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and the Rams and Seahawks each have a 50% chance of covering the spread, while the over/under total of 42.5 points has a 54% chance of going over.

As always, these predictions and probabilities are accurate at the time of publication but are subject to change.

Rams vs. Seahawks best bet

Our top pick for the Rams vs. Seahawks Week 16 NFL matchup is to bet on Over 42.5 points (-105).

This betting advice is formulated through comprehensive simulations and valuable betting intelligence, designed to bring you the best possible plays.

Score prediction for Rams vs. Seahawks

Dimers’ projected final score for the LA Rams vs. Seattle game on Thursday has the Seahawks winning 22-20.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Thursday

NFL props are an enjoyable way to wager on Thursday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Rams and Seahawks, as well as projected player stats.

Los Angeles RamsFirst touchdown scorer predictionsKyren Williams: 10.2% probabilityPuka Nacua: 9.2% probabilityColby Parkinson: 6.0% probabilityAnytime touchdown predictionsKyren Williams: 44.3% probabilityPuka Nacua: 41.1% probabilityColby Parkinson: 29.3% probabilityProjected box score leadersQB passing yards: Matthew Stafford, 242 yardsReceiving yards: Puka Nacua, 95 yardsRushing yards: Kyren Williams, 61 yardsSeattle SeahawksFirst touchdown scorer predictionsJaxon Smith-Njigba: 10.8% probabilityZach Charbonnet: 7.8% probabilityKenneth Walker: 7.4% probabilityAnytime touchdown predictionsJaxon Smith-Njigba: 42.8% probabilityZach Charbonnet: 33.3% probabilityKenneth Walker: 32.1% probabilityProjected box score leadersQB passing yards: Sam Darnold, 228 yardsReceiving yards: Jaxon Smith-Njigba, 92 yardsRushing yards: Kenneth Walker, 50 yardsNFL Week 16: Rams vs. Seahawks

Get ready for Thursday’s matchup between the Rams and Seahawks in Week 16 of the NFL season at Lumen Field, which is scheduled to start at 8:15 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets in this article are based on 10,000 data-driven simulations of the Rams vs. Seahawks matchup, and they are accurate at the time of publication. They aim to assist you make more informed choices when placing bets at online sportsbooks.

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