For Sunday’s game, which kicks off at 1 p.m. ET on CBS, sportsbooks have installed player props on Shedeur Sanders. Sanders and the Cleveland Browns (3-11) square off against the Buffalo Bills (10-4) in Week 16 at Huntington Bank Field in Cleveland, Ohio.

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Shedeur Sanders week 16 player propsMatchup: Cleveland Browns vs. Buffalo BillsTime: 1 p.m. ETDate: December 21, 2025Passing yards prop: Over 173.5 (-115)Rushing yards prop: Over 10.5 (-111)

National Football League odds courtesy of BetMGM. Odds updated Wednesday at 10:04 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Shedeur Sanders passing stats and trendsCompared to his 173.5-yard prop bet total for this matchup, Sanders is throwing for more yards per game this year (189.2).In three of five matchups this season, he has thrown for more than 173.5 yards.Sanders’ passing yards average (189.2) is higher than his average prop total this year (161.5) by 27.7 yards.Sanders has topped his passing yards prop total in three of four opportunities this year.He has a passing touchdown in three of five games this season, with multiple passing TDs in one of them.Sanders has been intercepted in four games this season (out of five), but had multiple picks on just one occasion.Browns vs. Bills stats and trendsThe 169.5 yards per game the Bills are conceding through the air makes them the NFL’s second-ranked pass defense.While the Browns rank third-worst in the NFL in passing offense with 171.9 passing yards per game, it’s been a different story on defense, as they rank best (169.0 passing yards per game allowed).While the Browns’ run defense ranks 14th with 110.1 rushing yards allowed per game, they’ve been less successful on offense, ranking fourth-worst (92.4 rushing yards per game).While the Browns rank worst in the NFL in yards per play at 4.6, it’s been a different situation defensively, as they rank fifth-best (5.1 yards per play allowed).

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