The Philadelphia Eagles visit the Washington Commanders this Saturday with a massive opportunity to clinch the NFC East title and punch their ticket to the postseason. While Washington has been eliminated from playoff contention, Philadelphia is fighting to become the first team in 20 years to win the division in consecutive seasons.

The Eagles’ quest for the crown will continue without two of their most dominant forces. Both defensive tackle Jalen Carter and All-Pro right tackle Lane Johnson have been ruled out for the Saturday clash. Carter is sidelined with shoulder injuries, while Johnson will miss his fifth straight game with a foot ailment, leaving veteran backup Fred Johnson to anchor the blindside.

Washington faces its own trench crisis as Pro Bowl left tackle Laremy Tunsil has also been ruled out. Furthermore, with star rookie Jayden Daniels sidelined for the remainder of the season, the Commanders will turn to veteran Marcus Mariota to lead the offense against an Eagles defense fresh off a dominant shutout victory.

The absence of three Pro Bowl-caliber linemen and a starting quarterback prompted analysts to urgently reevaluate Eagles vs. Commanders predictions. New simulations focus on how both offenses will adapt to reshuffled protection and the impact of Mariota’s veteran presence in this rivalry game.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Eagles-Commanders preview below.

Eagles vs. Commanders betting preview

Explore the interactive widget below to see the latest spread, over/under, and moneyline odds and probabilities for the Eagles-Commanders game at Northwest Stadium.

This prediction and best bet for Saturday’s NFL matchup between the Eagles and Commanders is from Dimers.com, a reliable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Eagles vs. Commanders matchup, including where the game is and what time it kicks off.

Teams: Philadelphia Eagles vs. Washington CommandersDate: Saturday, December 20, 2025Kickoff: 5 p.m. ESTLocation: Northwest StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Eagles-Commanders NFL matchup.

Spread: Eagles -7 (-104), Commanders +7 (-110)Moneyline: Eagles -320, Commanders +280Total: Over/Under 44.5 (-105/-110)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Eagles vs. Commanders

Using cutting-edge data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Saturday’s Eagles vs. Commanders game.

According to Dimers’ popular predictive analytics model, the Eagles are more likely to defeat the Commanders at Northwest Stadium. This prediction is based on the model giving the Eagles a 70% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the Commanders (+7) have a 57% chance of covering the spread, while the 44.5-point over/under has a 55% chance of going over.

These predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Eagles vs. Commanders best bet

Our top pick for the Eagles vs. Commanders Week 16 NFL matchup is to bet on the Commanders +7 (-110).

This betting advice is based on detailed simulations and valuable wagering intelligence, designed to assist you in making smarter decisions.

Score prediction for Eagles vs. Commanders

Dimers’ projected final score for the Philadelphia vs. Washington game on Saturday has the Eagles winning 25-19.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Saturday

NFL player prop picks are an enjoyable way to wager on Saturday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Eagles and Commanders, along with projected player stats.

Philadelphia EaglesFirst touchdown scorer predictionsSaquon Barkley: 10.8% probabilityJalen Hurts: 10.3% probabilityA.J. Brown: 9.5% probabilityAnytime touchdown predictionsSaquon Barkley: 46.1% probabilityJalen Hurts: 44.5% probabilityA.J. Brown: 42.1% probabilityProjected box score leadersQB passing yards: Jalen Hurts, 226 yardsReceiving yards: A.J. Brown, 69 yardsRushing yards: Saquon Barkley, 79 yardsWashington CommandersFirst touchdown scorer predictionsChris Rodriguez: 7.3% probabilityTerry McLaurin: 6.3% probabilityDeebo Samuel: 5.4% probabilityAnytime touchdown predictionsChris Rodriguez: 35.2% probabilityTerry McLaurin: 31.3% probabilityDeebo Samuel: 27.5% probabilityProjected box score leadersQB passing yards: Marcus Mariota, 210 yardsReceiving yards: Terry McLaurin, 61 yardsRushing yards: Chris Rodriguez, 47 yardsNFL Week 16: Eagles vs. Commanders

Get ready for Saturday’s action between the Eagles and Commanders in Week 16 of the National Football League season at Northwest Stadium, which is scheduled to start at 5 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets in this preview are based on 10,000 data-driven simulations of the Eagles vs. Commanders matchup, and they are correct at the time of publishing to help you make more informed choices when placing bets at online sportsbooks.

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