The Arizona Cardinals (3-11) are an underdog by 3 points as they aim to end a six-game slide in a matchup against the Atlanta Falcons (5-9) on Sunday, December 21, 2025 at State Farm Stadium.

Falcons vs. Cardinals game infoGame day: Sunday, December 21, 2025Game time: 4:05 p.m. ETTV channel: FOXLocation: Glendale, ArizonaStadium: State Farm StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Atlanta Falcons vs. Arizona Cardinals on Fubo! (Regional restrictions may apply)

Falcons vs. Cardinals odds & betting linesSpread favorite: Atlanta (-3)Moneyline: Atlanta (-157), Arizona (+132)Total: 48 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Falcons vs. Cardinals recent matchupsArizona and Atlanta have split their past four matchups (2-2).Atlanta has had the upper hand scoring in those four matchups, scoring 116 points against Arizona’s 92.Falcons vs. Cardinals betting insightsAtlanta has seven wins against the spread through 14 opportunities this season (7-7-0). The Falcons have been favored on the moneyline five times this season, and they have gone 1-4 in those games. Arizona has won six games against the spread so far this season (6-8-0). The Cardinals have a 1-10 record this year in games they have played as the moneyline underdog.Falcons scoring insightsThe Falcons’ scoring average at home, 20.7 points per game, is better than their average away, 19.6.On defense, Atlanta’s average at home, 27.5 points conceded, is higher than its average on the road, 22.0.The Falcons are putting up 20.0 points per game in divisional matchups, which is slightly lower than their 20.1 average outside the division.Atlanta has conceded 24.2 points per game in the division, which is a little better than its average outside the division of 24.4.Over the Falcons’ most recent three-game stretch, they rank 20th in scoring offense (20.7 points per game) and 27th in scoring defense (30.7 points per game allowed).Cardinals scoring insightsAt home, the Cardinals’ scoring average is 22.0 points per game, which is slightly higher than their average away, 21.1.Defensively, Arizona allows more points at home (29.6 per game) than away (25.9).On offense, the Cardinals are putting up 19.2 points per game in divisional matchups, which is less than their 22.9 average versus the rest of the league.Arizona has conceded 33.8 points per game in the division, which is worse than its mark outside the division of 24.3.In their past three games, the Cardinals are scoring 18.0 points per game (fifth-worst in NFL), and allowing 35.0 per game (third-worst).Falcons injury reportFalcons:
Leonard Floyd: Full Participation in Practice (Illness),
Mike Hughes: Did Not Participate In Practice (Ankle),
Khadarel Hodge: Did Not Participate In Practice (Shoulder),
Brandon Dorlus: Did Not Participate In Practice (Illness),
Drake London: Limited Participation in Practice (Knee),
DeAundre Alford: Full Participation in Practice (Illness),
Ruke Orhorhoro: Limited Participation in Practice (Groin),
Bijan Robinson: Full Participation in Practice (Illness),
LaCale London: Limited Participation in Practice (Shoulder),
Kyle Pitts: Limited Participation in Practice (Knee),
Jessie Bates III: Limited Participation in Practice (NIR – Rest),
Easton Stick: Did Not Participate In Practice (NIR – Personal)Cardinals injury reportCardinals:
Budda Baker: Full Participation in Practice (Thumb),
Xavier Weaver: Limited Participation in Practice (Hamstring),
Dadrion Taylor-Demerson: Limited Participation in Practice (Ankle),
Cody Simon: Limited Participation in Practice (Knee),
Marvin Harrison Jr.: Limited Participation in Practice (Heel),
Jalen Thompson: Did Not Participate In Practice (Hamstring),
Josh Sweat: Limited Participation in Practice (Rest),
Max Melton: Did Not Participate In Practice (Heel),
Paris Johnson Jr.: Did Not Participate In Practice (Knee),
Darren Hall: Did Not Participate In Practice (Concussion),
Evan Brown: Did Not Participate In Practice (Personal),
Kelvin Beachum: Did Not Participate In Practice (Rest),
Will Johnson: Full Participation in Practice (Thumb),
L.J. Collier: Full Participation in Practice (Knee)

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