Its a battle of division leaders when the Jaguars (10-4) travel to Denver to take on the Broncos (12-2).

Bo Nix and the Broncos sit not just atop the AFC West but the entire AFC. They have won 11 straight games. Denver can clinch the AFC West title for the first time since 2015 with a win and a Chargers loss/tie in Dallas. Take it a step further and if the Patriots lose to the Ravens Sunday night in Baltimore and the Bills somehow lose to or tie the Browns in Cleveland, the Broncos clinch the No.1 overall seed in the AFC.

The Jaguars have ridden a white-hot offense to the top of the AFC South. Trevor Lawrence and co. have won their last five games averaging 34.2pts/gm. They can clinch a playoff berth this weekend with a win coupled with a loss or a tie by either Indianapolis or Houston. If they do win, the Jags will have earned 11 for the first time since 2007.

Lets dive into the numbers and see if we can find an advantage.

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Game Details and How to Watch the Jaguars vs. Broncos live SundayDate: Sunday, December 21, 2025Time: 4:05PM ESTSite: Empower Field at Mile HighCity: Denver, CONetwork/Streaming: FOX

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Game Odds: Jaguars at Broncos

The latest odds as of Friday courtesy of DraftKings:

Moneyline: Jacksonville Jaguars (+154), Denver Broncos (-185)Spread: Broncos -3.5Total: 47.5 points

This game opened at Broncos -2.5 with the Game Total set at 43.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup: Jacksonville at DenverJaguars Starting QB: Trevor Lawrence
Last Game: 12/14 vs. Jets – 20-32, 330yds, 5TDs, 0INTs, 0 Sacks, 5 carries for 51yds rushing
Season: 14GP, 273-457, 3210yds, 23TDs, 11INTs, Sacked 32 times, 66 carries for 302yds rushingBroncos Starting QB: Bo Nix
Last Game: 12/14 vs. Green Bay – 23-34, 302yds, 4TDs, 0INTs, 0 Sacks, 7 carries for 10yds rushing
Season: 14GP, 320-504, 3256yds, 23TDs, 9INTs, Sacked 16 times, 62 carries for 254yds rushingJaguars at Broncos: Team Stats and Betting TrendsLast week, Trevor Lawrence became the first player in NFL history to have 5 TD passes, 1 TD run & 50+ rush yds in a single gameLawrence has gone 3 straight games without a turnover, the longest streak of his careerDenver has 11 wins this season when trailing, tied with last season’s Chiefs for the most in a season in NFL historyThe Broncos lead the NFL with 58 sacks this season, 10 more than the next closest teamWith 3 more TD, Bo Nix will join Justin Herbert as the only QBs in NFL history with 30+ total TD in each of a player’s first 2 seasonsDenver is 6-7-1 ATS this seasonJacksonville is 9-5 ATS this seasonThe OVER has cashed in 8 of the Jaguars 14 games this season (8-6)The OVER has cashed in 6 of the Broncos 14 games this season (6-8)

Holley: Nix playing well ahead of game vs. Jaguars

Mike Florio and Michael Holley preview Week 16 between the Jacksonville Jaguars and Denver Broncos, discussing how each head coach has helped their quarterbacks take the next step.

Jaguars Player InjuriesRB Bhayshul Tuten (finger) is listed as doubtful for Sunday’s gameLT Walker Little (undisclosed) is listed as questionable for Sunday’s gameLG Ezra Cleveland (shoulder) is listed as questionable for Sunday’s gameDE Josh Hines-Allen (illness) is listed as questionable for Sunday’s gameDE Danny Striggow (ankle) is listed as questionable for Sunday’s gameLB Jalen McLeod (ankle) is eligible to be activated from the IRBroncos Player InjuriesLB Justin Strnad (ankle) is listed as questionable for Sunday’s gameLB Karene Reid (hamstring) is eligible to be activated off the IROG Ben Powers (biceps) is eligible to be activated off the IRLB Drew Sanders (foot) is eligible to be activated off the IRRotoworld Best Bets

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Jaguars and the BroncosMoneyline: Rotoworld Bet is staying away from a play on the Moneyline.Spread: Rotoworld Bet is leaning towards a play ATS on the Jacksonville Jaguars at +3.5.Total: Rotoworld Bet is leaning towards a play on the UNDER on the Game Total of 47.5.

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