Christian McCaffrey, who is coming off a one-touchdown, 73-yard rushing effort in his last game, will lead the San Francisco 49ers against the Indianapolis Colts in Week 16 on Monday at 8:15 p.m. ET.
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Will Christian McCaffrey play this week?McCaffrey (full participation in practice, nir – rest) has been listed on the 49ers’ injury report this week, but he does not currently have an injury designation for the game.No other running back is listed on the injury report for the 49ers.Christian McCaffrey’s 2025 statsThis season McCaffrey has taken 259 carries for a team-best 922 yards (65.9 ypg) while scoring nine rushing TDs.McCaffrey also has a team-best 820 receiving yards (58.6 ypg) on 86 catches while hauling in five touchdown passes.49ers’ next gameMatchup: San Francisco 49ers at Indianapolis ColtsTime: 8:15 p.m. ETDate: December 22, 2025TV channel: ESPNLive stream: Fubo (Regional restrictions may apply)
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Christian McCaffrey’s 2025 game logWeek 1 at Seahawks: 22 CAR, 69 YDS, 0 TD, 9 REC, 73 YDSWeek 2 at Saints: 13 CAR, 55 YDS, 0 TD, 6 REC, 52 YDS, 1 REC TDWeek 3 vs. Cardinals: 17 CAR, 52 YDS, 0 TD, 10 REC, 88 YDSWeek 4 vs. Jaguars: 17 CAR, 49 YDS, 0 TD, 6 REC, 92 YDS, 1 REC TDWeek 5 at Rams: 22 CAR, 57 YDS, 0 TD, 8 REC, 82 YDS, 1 REC TDWeek 6 at Buccaneers: 17 CAR, 54 YDS, 1 TD, 7 REC, 57 YDSWeek 7 vs. Falcons: 24 CAR, 129 YDS, 2 TD, 7 REC, 72 YDSWeek 8 at Texans: 8 CAR, 25 YDS, 0 TD, 3 REC, 43 YDSWeek 9 at Giants: 28 CAR, 106 YDS, 1 TD, 5 REC, 67 YDS, 1 REC TDWeek 10 vs. Rams: 12 CAR, 30 YDS, 0 TD, 8 REC, 66 YDSWeek 11 at Cardinals: 13 CAR, 81 YDS, 2 TD, 5 REC, 40 YDS, 1 REC TDWeek 12 vs. Panthers: 24 CAR, 89 YDS, 1 TD, 7 REC, 53 YDSWeek 13 at Browns: 20 CAR, 53 YDS, 1 TD, 4 REC, 21 YDSWeek 15 vs. Titans: 22 CAR, 73 YDS, 1 TD, 1 REC, 14 YDS
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