A Saturday NFL doubleheader is the perfect treat for what is shaping up to be one of the best football weekends of the year. The day kicks off with the already-eliminated Washington Commanders hosting the NFC East-leading Philadelphia Eagles in an NFC East rivalry game.

The Eagles vs. Commanders kicks off at 5 p.m. ET on Saturday from Arlington, Va., live on FOX in NFL Week 16.

If the Eagles magic number to get into the playoffs is one: if they win this week, or the Cowboys lose, they’ll win the NFC East for the second-straight year. They’ll have a chance to take care of business on the road today.

Below, we’ll give you an Eagles vs. Commanders pick on the over/under for PrizePicks Team Picks in the NFL Saturday game. Use PrizePicks to make NFL picks and earn money if you’re right.

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Eagles vs. Commanders Over/Under, Spread for Saturday NFL Game

The Commanders opened the week as 5.5-point homeunderdogs vs. the Eagles. Since then, they have moved to 6.5-point underdogs on PrizePicks Team Picks. 

As the current favorites, the Eagles return a 1.26x payout on PrizePicks Team Picks if they win outright.

The Commanders are home underdogs with a 3.57x payout if they win, via PrizePicks Team Picks.

Spread: Philadelphia Eagles -7.5 (2x payout)Over/Under: 45.5 (2.04x payout on Over)Game Winner Payout: Commanders 3.57x | Eagles 1.26x

Team Picks payouts are live as of publishing and are subject to change.

Commanders vs. Eagles Prediction on Over/Under for Saturday Football

The Eagles vs. Commanders over/under opened the week at 44.5, and has ticked up to 45.5 on Team Picks. This total comes in as the sixth-lowest total on the Week 16 slate, out of 16 games.

Here are some stats to know to get you prepared for Eagles vs. Commanders, including an over/under prediction for Saturday via PrizePicks Team Picks.

After Week 14, the under is 101-72-4 (58%) in divisional games in outdoor conditions — highlighting a familiarity in scheme and personnel from rivalry matchups earlier in the season.When the total is between 43 and 47 in divisional games past Week 14, the under is 125-99-6 (56%).The Eagles defense ranks second in expected points average (EPA) per play vs the pass at -.13 but only 16th in EPA vs the run at -.03, signaling a potential run-funnel leaning defense.Since Kellen Moore became the offensive coordinator, in 2024 the Eagles have ranked in the bottom five in pass rate over expectation.In 838 snaps with the lead in 2024, the Eagles pass rate dropped to a miniscule 40%. This is notable as the Eagles are 6.5-point favorites on Saturday.Both teams are ranked in the bottom five in passing play percentage, with the Commanders ranked 28th at 51.98% and the Eagles 29th at 51.81%. Both teams may lean on their run game here; if so, we could see a running clock for the majority of the game.The Commanders rank 23rd in offensive plays per game at 59.6.The Eagles rank 24th in offensive plays per game at 59.1.Since their bye week, the Eagles are a perfect 6-0 towards the under, with the games combining for an average of 33 points per game.Commanders games have gone 7-7 to the over/under in 2025; however, that number is 5-2 to the over in Marcus Mariota starts.Both teams are missing one key offensive tackle with the Commanders ruling out PFF’s seventh-ranked OT Laremy Tunsil. The Eagles will be without PFF’s 19th-ranked OT Lane Johnson.

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Make Eagles vs. Commanders Picks on PrizePicks

The Eagles vs. Commanders kicks off an exciting Week 16 Saturday doubleheader. The Eagles will be looking to win the NFC East for the second year in a row, while the Commanders will try play spoiler at home with Marcus Mariota at QB.

This game serves as a tasty appetizer to the main course Packers vs. Bears game on Saturday Night — a battle for first place in the NFC North.

In the Eagles vs. Commanders game in NFL Week 16, there are plenty of NFL picks to consider on PrizePicks. You can pick teams to win, or cover the spread, or just pick 2-6 players, predict More or Less for their projected stats, and earn real money if you’re right.

Keep it locked in here with PrizePicks and the Playbook for continued NFL picks, predictions, and news all season long.