The Tampa Bay Buccaneers (7-7) and Carolina Panthers (7-7) meet Sunday in a Week 16 matchup at Bank of America Field in Charlotte, North Carolina. Kickoff is scheduled for 1 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Buccaneers vs. Panthers odds and make our expert NFL picks and predictions for the best bets.

Panthers lead all-time series 25-24, although the Buccaneers swept the season series in 2024. Tampa Bay won 26-23 in overtime last season on Dec. 1, 2024, although Carolina covered as a 6.5-point underdog as the Over (46) cashed. The Bucs have won 5 in a row, and 9 of the past 10 in the series, while going 7-3 against the spread (ATS) in that 10-game span. The Over is 4-1 in the past 5 in the series, too.

Tampa Bay and Carolina are battling for the top spot in the NFC South, and it’s a spot nobody seems to want. The Buccaneers have dropped 5 of the past 6 games, while going 0-6 ATS, including home wins against division rivals the Atlanta Falcons and New Orleans Saints. The teams meet again in Week 18

The Bucs lost 29-28 as 6.5-point favorites last week against the Falcons as the Over (43) cashed. Against Atlanta, QB Baker Mayfield threw for 277 yards and 2 TDs, while WR Mike Evans hauled in 6 receptions for 132 yards.

The Panthers inexplicably lost 20-17 in New Orleans last Sunday as a 2.5-point favorite, and they were swept in the 2-game season series by the Saints. QB Bryce Young threw for 163 yards and a TD, while RB Rico Dowdle posted 49 rushing yards and a score. WR Jalen Coker led the way with 60 receiving yards and a TD.

Carolina has dropped 3 of the past 5 games, while going 2-3 ATS in the span. The Under is 4-2 in the past 6 games, too.

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Buccaneers at Panthers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:49 p.m. ET.

Moneyline (ML): Buccaneers -155 (bet $155 to win $100) | Panthers +130 (bet $100 to win $130)Against the spread: Buccaneers -3 (-105) | Panthers +3 (-115)Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Buccaneers at Panthers key injuries

Buccaneers

Panthers

OT Ikem Ekwonu (knee) questionableDE Tershawn Wharton (hamstring) outWR David Moore (elbow) outLB Trevin Wallace (shoulder) outBuccaneers at Panthers picks and predictionsPrediction

Buccaneers 23, Panthers 19

The BUCCANEERS (-155) aren’t priced out of line if you’re on the conservative side, and you just want to bet a winner straight up without messing around with the points.

Honestly, the way these teams have been playing lately, neither team gives bettors a lot of confidence. But, Mayfield and the Bucs have just a little more experience in these type of games, and they’re a bit deeper on offense.

The lean is to the BUCCANEERS -3 (-105), but don’t get carried away.

Again, Tampa Bay has lost and failed to cover the past 2 games against divisional foes at home as a favorite, so going on the road against the other top team in the division will be no picnic.

However, the Panthers are just too inconsistent to trust. One week they’re topping a top team in the NFC, such as their Week 13 upset of the Los Angeles Rams, and then the next time out, after 2 weeks of preparation following a bye, they’re losing in New Orleans to a team which enters with just 3 wins. Make it make sense.

UNDER 45.5 (-110) might be the best play on the board.

The Under is 4-2 in the past 6 games for the Panthers, and Carolina has mustered 17 or fewer points in 6 of the past 8 outings.

The Buccaneers have cashed the Over in the past 2 games, but on the road, the Under is 3-1 in the past 4 tries. Tampa has managed 17.8 PPG in the past 4 road games.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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