Bills at Browns odds, picks and predictions

The Buffalo Bills (10-4) and Cleveland Browns (3-11) meet Sunday in a Week 16 matchup at Huntington Bank Field in Cleveland, Ohio. Kickoff is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Browns odds and make our expert NFL picks and predictions for the best bets.

The Browns lead all-time series 13-10, although the Bills won 31-23 in most recent meeting in Buffalo in 2022. The home team has won 5 in a row in the series. The Bills were the last road team to win, posting a 24-14 victory in 2012 in Cleveland.

The Bills registered a scintillating 35-31 comeback road win against the New England Patriots last week, erasing a 21-0 deficit, while covering as 2.5-point favorites as the Over (49) cashed. QB Josh Allen threw for 193 yards and 3 TDs, while RB James Cook rushed for 107 yards and 2 scores, and TE Dawson Knox posted a pair of TD catches.

Buffalo has won 3 in a row, averaging 33.4 points per game (PPG). It has also allowed 32.5 PPG in the past 2 outings, and the Bills have alternated covers and non-covers in each of the past 7 outings. The Over has cashed in the past 2 games.

The Browns were blasted 31-3 at the Chicago Bears last week, coming nowhere near a cover as 7-point underdogs as the Under (38) cashed. QB Shedeur Sanders threw 3 interceptions after a big showing in the week prior. Cleveland is 0-3 SU and against the spread (ATS) in the past 3 games, while the Under is 3-1 in the past 4 outings.

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Bills at Browns odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:21 p.m. ET.

Moneyline (ML): Bills -625 (bet $625 to win $100) | Browns +450 (bet $100 to win $450)Against the spread: Bills -10.5 (-105) | Browns +10.5 (-115)Over/Under (O/U): 41.5 (O: -110 | U: -110)

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Bills at Browns key injuries

Bills

WR Mecole Hardman (calf) questionableDB Cam Lewis (hamstring) questionableOT Chase Lundt (knee) outDT Jordan Phillips (ankle) outPK Matt Prater (quadriceps) out

Browns

OT Jack Conklin (concussion) outLB Sam Kamara (elbow) questionableCB Denzel Ward (calf) outQB Deshaun Watson (Achilles) outBills at Browns picks and predictionsPrediction

Bills 38, Browns 13

The Bills (-625) will cost you more than 6 times your potential return, and that’s obviously way too much risk for not nearly enough return. A $100 wager will return just $16 of profit.

The Bills are unlikely to lose outright to the Browns, who appear to be in full tank mode, but anything can happen.

AVOID.

Back the BILLS -10.5 (-105), as they look to keep their AFC East Division title hopes on track.

The Browns have long since been eliminated, and this is a team which was dusted in Chicago against another contender last week, and one which lost at home to the lowly Tennessee Titans in the most recent showing at home. Cleveland is also 0-3 ATS in the past 3 games, and they’ve lost the past tries against AFC East teams which also going 0-2 ATS. They’ve averaged 16.5 PPG in those 2 losses, while allowing 29.5 PPG.

OVER 41.5 (-110) is a strong play, and it wouldn’t be shocking to see Buffalo come really close to hitting it all on its own.

The Browns have allowed 31 points in each of the past 2 games against the Titans and Bears, and Cleveland has allowed 26.7 PPG in the past 3 home outings.

The Bills have registered at least 35 points in 3 of the past 5 games, while allowing 30+ in 4 of the previous 6 outings, too.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Bills at Browns odds, picks and predictions

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