Arizona (3-11) rides a six-game losing streak into a matchup with (-) on Sunday, December 21, 2025 at State Farm Stadium. The Falcons are listed as favorites in this one, with the spread sitting at 3 points. The over/under is 48.5 in the contest.
The Cardinals lost against the Houston Texans in their last game, 40-20.
The Cards’ Jacoby Brissett was 27-for-40 for 249 yards versus the Texans, with three TDs and one INT.
The Falcons won against the Tampa Bay Buccaneers in their most recent game, 29-28.
Cardinals vs Falcons betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:59 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Atlanta (-3)Moneyline: Atlanta (-157), Arizona (+132)Total: 48.5 pointsCardinals betting insightsArizona has covered the spread once at home, and is 1-6 overall there this year.The Cardinals have compiled a 6-8-0 record against the spread this year.At home, Arizona has one win ATS (1-2) as 3-point underdogs or greater.The Cardinals have an ATS record of 4-4 when playing as at least 3-point underdogs.This season, in seven games at home, Arizona has hit the over six times.Cardinals games have gone over the total nine times this season.Cardinals leadersBrissett: 2,708 PASS YDS / 246.2 YPG / 66.3% / 18 TD / 6 INT / 34 CAR / 144 RUSH YDS / 1 TDEmari Demercado: 32 CAR / 242 YDS / 26.9 YPG / 0 TD / 10 REC / 64 YDS / 7.1 YPG / 1 TDMichael Carter: 67 CAR / 221 YDS / 22.1 YPG / 1 TD / 28 REC / 232 YDS / 23.2 YPG / 0 TDTrey McBride: 105 REC / 1,071 YDS / 76.5 YPG / 10 TDMichael Wilson: 66 REC / 766 YDS / 54.7 YPG / 4 TDMarvin Harrison Jr.: 40 REC / 594 YDS / 59.4 YPG / 4 TDCardinals vs Falcons game infoDate: Sunday, December 21, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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