The Buffalo Bills visit Cleveland today with a chance to officially clinch a playoff berth. While Buffalo seeks postseason security, they must first survive a historic threat: Browns pass rusher Myles Garrett, who sits just 1.5 sacks away from the all-time NFL single-season record.

To neutralize Garrett, Buffalo will lean on its league-leading “YAC” attack featuring tight ends Dalton Kincaid and Dawson Knox. Defensively, Sean McDermott looks to improve his 9-3 career record against rookie quarterbacks as he schemes for Cleveland’s Shedeur Sanders. Between Garrett’s record chase and the Bills’ clinch scenarios, experts have performed a final reevaluation of today’s projections.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Browns gameday preview below.

Bills vs. Browns betting preview

Explore the interactive widget below to view the latest spread, total, and moneyline odds and probabilities for the Bills-Browns game at Huntington Bank Field.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Browns is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bills vs. Browns matchup, including where the game is and what time it kicks off.

Teams: Buffalo Bills vs. Cleveland BrownsDate: Sunday, December 21, 2025Kickoff: 1 p.m. ESTLocation: Huntington Bank FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL showdown between the Bills and Browns.

Spread: Bills -10.5 (-105), Browns +10.5 (-115)Moneyline: Bills -625, Browns +490Total: Over/Under 41.5 (-108/-110)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Expert prediction: Bills vs. Browns

Using state-of-the-art data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Bills vs. Browns game.

According to Dimers’ renowned predictive analytics model, the Bills are more likely to beat the Browns at Huntington Bank Field. This prediction is based on the model giving the Bills an 85% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the bookmakers have gotten it right and the Bills and Browns each have a 50% chance of covering the spread, while the 41.5-point over/under is also considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Bills vs. Browns best bet

Our top pick for the Bills vs. Browns Week 16 NFL matchup is to bet on the Bills moneyline (-625).

This betting advice is based on cutting-edge modeling and valuable wagering intelligence, designed to help you make smarter investments.

Score prediction for Bills vs. Browns

Dimers’ predicted final score for the Buffalo vs. Cleveland game on Sunday has the Bills winning 25-15.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL props are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bills and Browns, as well as projected player stats.

Buffalo BillsFirst touchdown scorer predictionsJames Cook: 13.2% probabilityJosh Allen: 11.1% probabilityKhalil Shakir: 5.3% probabilityAnytime touchdown predictionsJames Cook: 54.0% probabilityJosh Allen: 48.1% probabilityKhalil Shakir: 27.0% probabilityProjected box score leadersQB passing yards: Josh Allen, 214 yardsReceiving yards: Khalil Shakir, 47 yardsRushing yards: James Cook, 92 yardsCleveland BrownsFirst touchdown scorer predictionsQuinshon Judkins: 10.7% probabilityHarold Fannin: 5.0% probabilityJerry Jeudy: 3.5% probabilityAnytime touchdown predictionsQuinshon Judkins: 45.8% probabilityHarold Fannin: 25.0% probabilityJerry Jeudy: 18.2% probabilityProjected box score leadersQB passing yards: Shedeur Sanders, 182 yardsReceiving yards: Harold Fannin, 53 yardsRushing yards: Quinshon Judkins, 61 yardsNFL Week 16: Bills vs. Browns

Get ready for Sunday’s game between the Bills and Browns in Week 16 of the National Football League season at Huntington Bank Field, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets on this page are based on 10,000 data-driven simulations of the Bills vs. Browns matchup, and they are accurate at the time of publication. They aim to assist you make better decisions when placing bets at online sportsbooks.

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