For the 29th time in franchise history, the San Francisco 49ers have notched 10-plus wins in a season. Following a rare December bye week, the 49ers posted a 37-24 victory over the Tennessee Titans. Brock Purdy threw for three touchdowns with Jauan Jennings scoring twice, Christian McCaffrey totaled 23 touches, George Kittle tallied his sixth touchdown, and Eddy Piñeiro remained perfect in field goals.

Despite the win, the game had an ominous feel, especially defensively. The 49ers did not record a sack, create a turnover, and allowed 136 yards rushing. Although the result was not threatened, it seemed as though the 49ers could not deliver the knockout blow early in the game, while Tennessee continued to hang around. Ultimately, the efficiency on third down and dominance on time of possession won out.

Now sitting at 10-4 and coupled with Seattle’s thrilling victory over the Rams Thursday night, the 49ers now control their playoff destiny. One more win is almost assuredly enough to guarantee a playoff berth, while running the table would result in the NFC’s number one overall seed.

This week’s opponent is a primetime road showdown with Indianapolis. The Colts have essentially had a tale of two seasons, starting 7-1 but dropping five of six, including four straight. Quarterback Daniel Jones had been terrific before a torn Achilles in Week 14 ended his season.

With backups Anthony Richardson and Riley Leonard both down, the Colts have turned to the ageless wonder, Philip Rivers, at quarterback. San Francisco wants to strengthen their playoff positioning, while Indianapolis needs to stay afloat in the AFC. An intriguing matchup.

5 – Darrell Luter Jr.

Renardo Green will be out with a neck injury, so Upton Stout will be joined by Darrell Luter Jr., together and separately marking the Colts’ slot receivers. Luter mainly plays on special teams with 10 tackles on his stat sheet this season. He possesses good athleticism with physicality at the point of attack.

With old man Rivers behind center for Indy, the deep ball will be non-existent, so check downs, screens, crossers, and quick slants will be front and center for the Colts. Michael Pittman Jr. is the main receiving target, but Luter will likely deal with Alec Pierce and Josh Downs on those aforementioned routes.

4 – Alfred Collins

The 49ers hope to get back help on the defensive line with Sam Okuayinonu and Yetur Gross-Matos this week. The Colts’ offense runs through running back Jonathan Taylor, averaging nearly five and a half yards per rush, while leading the league in carries, rushing yards, and touchdowns. And with the uncertainty at quarterback from a production standpoint, Taylor will be featured early and often. The 49ers didn’t necessarily slow down Tony Pollard last week, either.

Alfred Collins will attempt to clog the interior along with Jordan Elliott and Kalia Davis to slow down Taylor. At 6-foot-5 and 330-plus pounds, Collins has the strength and length to make an impact at the line of scrimmage. His game-saving forced fumble and recovery against Kyren Williams in Week 4 remains one of the most coveted moments of the 49ers’ season so far.

3 – Kendrick Bourne

The productive game by Ricky Pearsall against Tennessee came at a cost: he suffered an ankle injury during the first offensive series and is ruled out against the Colts. Ever since his virtuoso 10-catch, 142-yard performance in Week 4, Kendrick Bourne has recorded just 15 receptions in the subsequent nine weeks, in part due to the usage of Christian McCaffrey and George Kittle, as well as the reemergence of Jauan Jennings (four touchdowns in the last three games).

If the 49ers can establish the run game early, there could be opportunities in the intermediate range for Bourne to catch and run.

2 – Tatum Bethune

An ankle injury sidelined Tatum Bethune for a month. Curtis Robinson stepped in and performed admirably during the 49ers’ current four-game win streak. The consistency has been there all season for Bethune ever since he replaced Fred Warner. Bethune has recorded 10+ tackles in five of his starts. He is very stout against the run, and that skill will be on display against Jonathan Taylor.

When Philip Rivers throws it straight and not towards a sideline, look for Bethune or Dee Winters in coverage on talented rookie Tyler Warren, a big threat especially in the red zone.

1 – Brock Purdy

The last time the 49ers were on primetime was a home Week 12 matchup with Carolina, prevailing in an ugly 20-9 win. The volume and effectiveness of Christian McCaffrey were ultimately the difference. What made the game ugly was Brock Purdy’s three first-half interceptions. Purdy bounced back nicely against Cleveland and Tennessee, accounting for five touchdowns.

Purdy has also shown recently to expand plays with his legs (48 rush yards last two games) rather than scrambling and throwing on the run. Sauce Gardner is out this week, but the Colts boast a young and athletic secondary, accounting for eight of their 12 interceptions so far this season.

Purdy wouldn’t even care if he got outplayed by his elder adversary in Rivers, as long as he continues to get the ball into his playmakers’ hands, and doesn’t make egregious throws into dangerous areas, the 49ers will be in good shape and expected to leave the Midwest with a win.