The San Francisco 49ers are traveling in Week 16 for an interconference matchup with the Indianapolis Colts on Monday night at Lucas Oil Stadium.
San Francisco has won four in a row since starting quarterback Brock Purdy returned from the toe injury that cost him eight starts. Their offense will be without second-year wide receiver Ricky Pearsall, who caught six passes for 96 yards last week against the Tennessee Titans. They’ll need to find someone else to make an impact in the passing game alongside George Kittle, Christian McCaffrey and Jauan Jennings.
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The Colts are going the opposite direction, losing their last four games after starting the year with an 8-2 record. With Daniel Jones and Anthony Richardson on injured reserve, they’ll give 44-year-old Philip Rivers his second start of the year.
Before these two teams meet on the field on Sunday, we’ve gone through picks from roughly 40 experts from different sites/publications to see who they’re taking in this matchup. Let’s take a look at what they said.
Here are all the top expert picks for 49ers vs. Colts in Week 16:
Mike Middlehurst-Schwartz: 49ers
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This article originally appeared on Niners Wire: 49ers-Colts: Who do experts think will win SF’s Week 16 game?