The Indianapolis Colts (8-6) are eyeing 16 players on their injury report as they prepare for a Monday, Dec. 22 matchup against the San Francisco 49ers (10-4) at Lucas Oil Stadium, which kicks off at 8:15 p.m. ET.
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Colts vs 49ers TV channel & game infoGame day: Monday, December 22, 2025Game time: 8:15 p.m. ETLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumTV channel: ESPNLive stream: Watch on Fubo! (Regional restrictions may apply)
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Colts injury reportBernhard Raimann | OT (Out)Injury: ElbowPractice Status: Limited Participation in Practice2025 Season Stats: 7 Games PlayedAnthony Richardson | QB (Out)Injury: EyePractice Status: Limited Participation in PracticeAnthony Gould | WR (Out)Injury: FootPractice Status: Did Not Participate In Practice2025 Season Stats: 10 Games PlayedSauce Gardner | CB (Out)Injury: CalfPractice Status: Did Not Participate In Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 33 Tackles | 0 Interceptions | 8 Passes DefendedDaniel Scott | S (Out)Injury: KneePractice Status: Full Participation in Practice2025 Season Stats: 2 Games PlayedDeForest Buckner | DT (Questionable)Injury: NeckPractice Status: Did Not Participate In Practice2025 Defensive Stats: 4.0 Sacks | 9.0 Tackles for Loss | 42 Tackles | 0 Interceptions | 0 Passes DefendedGermaine Pratt | LBInjury: PersonalPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 6.0 Tackles for Loss | 108 Tackles | 0 Interceptions | 7 Passes DefendedTyquan Lewis | DEInjury: ChestPractice Status: Full Participation in PracticeAlec Pierce | WRInjury: AchillesPractice Status: Full Participation in Practice2025 Receiving Stats: 68 Targets | 39 Receptions | 785 Yards | 2 TouchdownsQuenton Nelson | OGInjury: WristPractice Status: Full Participation in Practice2025 Season Stats: 2 Games PlayedJohnathan Edwards | CBInjury: IllnessPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 3 Passes DefendedJosh Downs | WRInjury: PersonalPractice Status: Full Participation in Practice2025 Receiving Stats: 70 Targets | 47 Receptions | 406 Yards | 4 TouchdownsAmeer Abdullah | RBInjury: KneePractice Status: Full Participation in Practice2025 Season Stats: 10 Games PlayedZaire Franklin | LBInjury: NIR – RestPractice Status: Did Not Participate In Practice2025 Defensive Stats: 2.0 Sacks | 5.0 Tackles for Loss | 104 Tackles | 0 Interceptions | 4 Passes DefendedSamson Ebukam | DEInjury: NIR – RestPractice Status: Limited Participation in Practice2025 Defensive Stats: 2.0 Sacks | 4.0 Tackles for Loss | 22 Tackles | 0 Interceptions | 0 Passes DefendedGrover Stewart | DTInjury: RestPractice Status: Full Participation in Practice2025 Defensive Stats: 0.5 Sacks | 5.0 Tackles for Loss | 47 Tackles | 1 Interception | 4 Passes DefendedColts insightsThe Colts have scored fewer points per game over their past three matchups (17) than they have averaged for the season (28).Turning our attention to yardage, Indianapolis has accumulated fewer total yards per game over its previous three matchups (262) than it has averaged for the season (357.9).In the passing game, the Colts have seen a dip in production over their last three games, racking up 169.7 passing yards per game, compared to their season-long average of 229 passing yards per contest.Indianapolis is running for 128.9 yards per contest this season, but it has been worse in the running game over its last three matchups, averaging 92.3 rushing yards per game.Colts vs 49ers odds
NFL odds courtesy of BetMGM. Odds updated Monday at 1:16 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-5.5)Moneyline: 49ers (-260), Colts (+210)Total: 46 points
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