On Monday at 8:15 p.m. ET, Mo Alie-Cox and the Indianapolis Colts meet the San Francisco 49ers in Week 16.

See how to see Alie-Cox play live in the article below.

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Alie-Cox’s next gameMatchup: Indianapolis Colts vs. San Francisco 49ersGame Date: December 22, 2025Game Time: 8:15 p.m.TV channel: ESPNLive stream: Fubo (regional restrictions may apply)Tickets: StubHubWill Alie-Cox play this week?Alie-Cox is not on the injury report this week.The Colts have three other receivers on the injury list this week:Alec Pierce (FP/achilles): 39 Rec; 785 Rec Yds; 2 Rec TDsAnthony Gould (out/foot): 2 Rec; 6 Rec Yds; 0 Rec TDsJosh Downs (FP/personal): 47 Rec; 406 Rec Yds; 4 Rec TDsAlie-Cox could be in line for a bigger role this week if the Colts’ one injured running back can’t play:Ameer Abdullah (FP/knee): 13 Rush Att; 59 Rush Yds; 1 Rush TD 12 Rec; 67 Rec Yds; 0 Rec TDsOne quarterback is listed on the Colts’ injury report:Anthony Richardson (out/eye): 1 Pass Comp; 2 Pass Att; 50.0 Pass Comp%; 9 Pass Yds; 0 Pass TDs; 4 Rush Att; -1 Rush Yds; 0 Rush TDs

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Alie-Cox’s season statsAlie-Cox’s 11 targets have led to five catches for 59 yards (7.4 per game).Alie-Cox’s 2025 game logWeek 1 vs. Dolphins: 1 TAR, 1 REC, 20 YDS, 0 TDWeek 2 vs. Broncos: 1 TAR, 1 REC, 8 YDS, 0 TDWeek 6 vs. Cardinals: 2 TAR, 1 REC, 16 YDS, 0 TDWeek 7 at Chargers: 2 TAR, 1 REC, 6 YDS, 0 TDWeek 9 at Steelers: 1 TAR, 0 REC, 0 YDS, 0 TDWeek 10 vs. Falcons: 1 TAR, 0 REC, 0 YDS, 0 TDWeek 12 at Chiefs: 1 TAR, 1 REC, 9 YDS, 0 TDWeek 14 at Jaguars: 2 TAR, 0 REC, 0 YDS, 0 TD

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