The San Francisco 49ers (10-4) visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET, in a matchup between a pair of the top offensive players in the NFL in Christian McCaffrey and Jonathan Taylor.
Offensively, the 49ers rank 10th in the NFL with 347.5 yards per game. Meanwhile, they rank 18th in total defense (333.6 yards allowed per contest). From an offensive perspective, the Colts are posting 357.9 total yards per game (seventh-ranked). They rank 22nd in the NFL on defense (342.7 total yards allowed per game).
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49ers vs Colts: live streaming info, TV channel & game timeGame day: Monday, December 22, 2025Game time: 8:15 p.m. ETLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumTV channel: ESPNLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
49ers vs Colts betting lines
NFL odds courtesy of BetMGM. Odds updated Monday at 4:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-5.5)Moneyline: 49ers (-260), Colts (+210)Total: 46 points
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