play

Lions’ playoff hopes fade after gut-wrenching loss vs. Steelers

USA TODAY Sports’ Prince Grimes ‘overreacts’ to some of the best games from Sunday’s Week 16 slate.

The Philadelphia Eagles and Buffalo Bills play on Dec. 28 at the Bills’ Highmark Stadium in a game on the NFL Week 17 schedule.

Which team will win the NFL Week 17 game?

Check out these NFL Week 17 picks and NFL Week 17 predictions for the game, which can be seen at 2:25 p.m. MST on FOX (stream with FUBO).

The Bills are a 2.5-point favorite over the Eagles in NFL Week 17 odds for the game, courtesy of BetMGM Sportsbook.

Buffalo is -140 on the moneyline, while Philadelphia is +115. The over/under (point total) is set at 44 points.

Watch Eagles at Bills live on FUBO (free trial)

Jeremy Cluff writes: “Could this game be a Super Bowl preview? Maybe. We hope these teams treat it as one. The edge in this one goes to the home team, which is 6-1 at Highmark Stadium, and has Josh Allen at quarterback.”

Bookies.com: Bet the Bills to cover vs Eagles

Bill Speros writes: “Tom Brady makes his final appearance at Highmark Stadium – in the booth for FOX. The Eagles clinched the NFC East in Week 16. They’re all-but locked into the No. 3 seed in the NFC. The Bills’ run of 5 straight AFC East championships may well be over before this one begins. The Patriots clinch the division with a win over the N.Y. Jets in the 1 p.m. Sunday slot. Still, the Bills need to win here to keep pace in the Wild Card race. Josh Allen & Co. are 6-1 at home this season and have won 5 straight outright. Plus, they cover against good teams at home. They’ve covered in their past 10 home games against teams with a winning record, not named the Patriots. Allen gets it done. Again.”

The site’s formula predicts that the Bills will win the NFL Week 17 game against the Eagles.

ESPN: Eagles have a 50% chance to beat Bills on Sunday

The site gives the Bills a 49.6% shot at winning the NFL Week 17 game, with the remaining percentage accounting for a tie.

Dimers: Bills 25, Eagles 22

It writes: “After extensive simulations, our model gives the Eagles a win probability of 39%, while the Bills have a win probability of 61%.”

Sportsnaut: Philadelphia Eagles 27, Buffalo Bills 24

Matt Johnson writes: “Entering Week 17, the Buffalo Bills have surrendered 143.6 rushing yards and 1.7 rushing touchdowns per game with a 5.3 yards-per-carry average in the last 10 contests. This is a great opportunity for a resurgent Philadelphia Eagles offense – 152.8 rush ypg and 5.0 ypc in last four weeks – to exploit Buffalo’s biggest weakness. Plus, Philadelphia’s defense is getting Jalen Carter back for Week 17 and this unit is perfectly equipped to shut down Josh Allen through the air.”

NFL’s highest paid players in 2025: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid NFL players: Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don’t miss a thing.