Oddsmakers give the New Orleans Saints (5-10) a small chance to keep their three-game winning streak going, as they are favored by 2.5 points in a matchup with the Tennessee Titans (3-12) on Sunday, December 28, 2025 at Nissan Stadium.

Saints vs. Titans game infoGame day: Sunday, December 28, 2025Game time: 1 p.m. ETTV channel: CBSLocation: Nashville, TennesseeStadium: Nissan StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Saints vs. Titans odds & betting linesSpread favorite: New Orleans (-2.5)Moneyline: New Orleans (-150), Tennessee (+126)Total: 39.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Saints vs. Titans recent matchupsNew Orleans has gone 2-1 versus Tennessee over the last three matchups between the two teams.New Orleans scored 75 points in those three matchups, with Tennessee putting up 66.Saints vs. Titans betting insightsNew Orleans has a 7-8-0 record against the spread this season. The Saints have won two of the three games they have played as the moneyline favorite this season. Tennessee has a 7-8-0 record against the spread so far this season. This will be the 16th game this year the Titans are an underdog on the moneyline. They are 3-12 in games as the underdog.Saints scoring insightsThe Saints’ scoring average at home, 17.6 points per game, is better than their average on the road, 16.3.On defense, New Orleans’ average at home, 19.4 points conceded, is lower than its average on the road, 26.1.The Saints have put up 14.8 points per game in the division, below their average against the rest of the league of 18.1.New Orleans is allowing 18.2 points per game in divisional matchups, which is lower than its 24.7 average versus the rest of the league.While the Saints rank 16th in points per game over the last three contests (24.3), they rank third-best on defense (14.3 points allowed per game) during that three-game period.Titans scoring insightsAt home, the Titans are averaging more points (17.3) than away (16.1).On defense, Tennessee is conceding 26.5 points per game at home, a little less than its 27.3 average on the road.On offense, the Titans average fewer points in division games (10.0) than outside the division (20.1).Tennessee has allowed 29.2 points per game in the division, which is worse than its average in non-division games of 25.7.The Titans are 10th in the NFL in points scored for the past three games (27.0 per game) and 15th in points allowed (25.0).Saints injury reportSaints:
Tyler Shough: Full Participation in Practice (Hip),
Asim Richards: Full Participation in Practice (Ankle),
Chris Olave: Full Participation in Practice (Back),
Mason Tipton: Limited Participation in Practice (Groin),
Nathan Shepherd: Limited Participation in Practice (Ankle),
Cesar Ruiz: Did Not Participate In Practice (Ankle),
Foster Moreau: Did Not Participate In Practice (Ankle),
Zaire Mitchell-Paden: Did Not Participate In Practice (Knee),
Alvin Kamara: Did Not Participate In Practice (Knee),
Davon Godchaux: Did Not Participate In Practice (Nir – Rest),
Bryan Bresee: Did Not Participate In Practice (Knee)Titans injury reportTitans:
Sebastian Joseph-Day: Limited Participation in Practice (Calf),
Gunnar Helm: Limited Participation in Practice (Toe),
Marcus Harris: Did Not Participate In Practice (Knee),
Cedric Gray: Full Participation in Practice (Concussion),
Ali Gaye: Full Participation in Practice (Knee),
Julius Chestnut: Full Participation in Practice (Back),
Jalyn Armour-Davis: Limited Participation in Practice (Achilles),
Kevin Zeitler: Limited Participation in Practice (Groin),
Bryce Oliver: Full Participation in Practice (Knee),
Femi M. Oladejo: Limited Participation in Practice (Fibula)

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