The Indianapolis Colts (8-7) are 6.5-point underdogs as they look to end their five-game losing streak in a matchup against the Jacksonville Jaguars (11-4) on Sunday, December 28, 2025 at Lucas Oil Stadium.

Jaguars vs. Colts game infoGame day: Sunday, December 28, 2025Game time: 1 p.m. ETTV channel: FOXLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

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Jaguars vs. Colts odds & betting linesSpread favorite: Jacksonville (-6.5)Moneyline: Jacksonville (-287), Indianapolis (+232)Total: 48.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Jaguars vs. Colts recent matchupsJacksonville holds the edge versus Indianapolis in the last five matchups between the two teams, putting together a 4-1 record.The Jaguars and Colts haven’t gone over the total in any of their past five matchups, but Jacksonville is 4-1 against the spread in those games.Jacksonville scored 164 points in those five matchups, with Indianapolis putting up 120.Jaguars vs. Colts betting insightsJacksonville has a 10-5-0 record against the spread so far this season. The Jaguars have put together a 6-0 record in the six games this season they have been the moneyline favorite. Indianapolis has an against-the-spread record of 8-7-0 so far this season. The Colts have a 2-4 record this year in games they have been an underdog on the moneyline.Jaguars scoring insightsThe Jaguars’ scoring average at home, 26.5 points per game, is lower than their average on the road, 28.3.Defensively, Jacksonville allows fewer points at home (18.5 per game) than on the road (23.4).The Jaguars have scored 26.8 points per game in the division, a tad below their average outside the division of 27.5.Jacksonville is giving up 17.0 points per game in divisional matchups, which is better than its 22.2 average outside the division.The Jaguars rank eighth in the NFL with 19.7 points per game allowed on defense over the previous three contests, but they’ve really been finding success on the offensive side of the ball, as they rank second-best with 39.3 points per game during that time frame.Colts scoring insightsAt home, the Colts are averaging more points (30.6) than away (24.9).On defense, Indianapolis’ average at home, 22.0 points conceded, is better than its average on the road, 25.0.On offense, the Colts are scoring 28.5 points per game in divisional contests, which is slightly better than their 27.7 average outside the division.Indianapolis averages fewer points allowed in division games (22.5) than non-division games (23.7).The Colts are 25th in the NFL in points scored for the past three games (20.7 per game) and fourth-worst in points allowed (34.0).Jaguars injury reportJaguars:
Greg Newsome II: Did Not Participate In Practice (Shoulder),
Jourdan Lewis: Did Not Participate In Practice (Foot),
Montaric Brown: Limited Participation in Practice (Neck),
Jalen McLeod: Limited Participation in Practice (Ankle),
Travon Walker: Full Participation in Practice (Knee),
Danny Striggow: Did Not Participate In Practice (Ankle),
Arik Armstead: Full Participation in Practice (Hand),
Patrick Mekari: Did Not Participate In Practice (Back),
Robert Hainsey: Did Not Participate In Practice (Groin),
Ezra Cleveland: Limited Participation in Practice (Shoulder),
Tim Patrick: Limited Participation in Practice (Foot),
Bhayshul Tuten: Limited Participation in Practice (Finger)Colts injury reportColts:
Tyler Goodson: Did Not Participate In Practice (Ankle),
Sauce Gardner: Did Not Participate In Practice (Calf),
Ashton Dulin: Full Participation in Practice (Hamstring),
DeForest Buckner: Did Not Participate In Practice (Neck),
Tanor Bortolini: Did Not Participate In Practice (Concussion),
J.T. Tuimoloau: Did Not Participate In Practice (Oblique),
Dalton Tucker: Did Not Participate In Practice (Shoulder),
Daniel Scott: Full Participation in Practice (Knee),
Anthony Richardson: Limited Participation in Practice (Eye),
Bernhard Raimann: Limited Participation in Practice (Elbow),
Andrew Ogletree: Did Not Participate In Practice (Neck),
Jaylon Jones: Full Participation in Practice (Knee),
Anthony Gould: Did Not Participate In Practice (Foot)

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