Two of Goff’s lost fumbles came from errant snaps by backup center Kingsley Eguakun. Jahmyr Gibbs lost one at the end of a run past midfield early in the second quarter. Goff was picked off by cornerback Byron Murphy and safety Harrison Smith in the third quarter. His only other five-turnover game in 10 seasons in the league was last year at Houston, when he had five interceptions in a 26-23 win.

Goff, who is third in the league in passer rating and second in passing yards and passing touchdowns, went 18 of 29 for 197 yards and one touchdown to Isaac TeSlaa.

“They had a good plan and exploited some things on us and were able to get after us, adding an extra rusher a lot of time,” Goff said. “We had a plan that we thought would attack that. It didn’t work well.”

The previous time Detroit had a six-turnover game was in 2015 in a 42-17 loss to Arizona, according to Sportradar data. The minus-6 turnover margin was the worst in the NFL this season and tied with five other teams for the worst in any game in the league in the past nine years.

The Vikings had five sacks and frequently pressured Goff on plays when they didn’t take him down.

“Anytime he’s not able to step in the throw, it’s going to be hard for him,” Lions coach Dan Campbell said. “That’s where he’s at his best, obviously, in the pocket. If he’s not able to at least hit that back foot and step into it, it makes it pretty difficult. That defense puts a lot on you, and it was a short week, and they really did a lot. They went all out.”

The rushing attack that fueled the Lions the past two years has lagged all season, and this was the game they needed it the most, with Gibbs and David Montgomery combining for just 66 yards on 27 carries behind a struggling offensive line.

The Lions lost two starters from last year’s group who haven’t been adequately replaced, and left tackle Taylor Decker was out on Thursday with a shoulder injury.

After the Lions stalled out near the goal line last week in their 29-24 loss at home to Pittsburgh to put them on the brink, the turnovers in Minnesota finished them off.

“The effort’s there,” Campbell said. “We’re just a little off here, and it’s costing us significantly.”