The Buffalo Bills (11-4) are favored by 1.5 points as they fight to keep their four-game winning streak going in a matchup against the Philadelphia Eagles (10-5) on Sunday, December 28, 2025 at Highmark Stadium.
Bills vs. Eagles game infoGame day: Sunday, December 28, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: Orchard Park, New YorkStadium: Highmark StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)
Watch Buffalo Bills vs. Philadelphia Eagles on Fubo! (Regional restrictions may apply)
Bills vs. Eagles odds & betting linesSpread favorite: Buffalo (-1.5)Moneyline: Buffalo (-120), Philadelphia (+101)Total: 44 points
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Bills vs. Eagles recent matchupsOver the last two matchups between Buffalo and Philadelphia, the Eagles are 2-0.Philadelphia put up 68 points in those two matchups, while Buffalo posted 47.Bills vs. Eagles betting insightsBuffalo, in 15 games with a spread this season, is 7-8-0 against the spread. The Bills have won nine of the 13 games they have played as the moneyline favorite this season. Philadelphia is 9-6-0 against the spread in 15 opportunities so far this season. This will be the first game this year the Eagles are an underdog on the moneyline.Bills scoring insightsThe Bills’ scoring average at home, 33.4 points per game, is higher than their average on the road, 25.0.On defense, Buffalo concedes more points at home (27.1 per game) than on the road (19.3).The Bills average fewer points in division games (25.8) than against the rest of the league (30.5).Buffalo has allowed 23.0 points per game in the division, which is not quite as good as its mark against the rest of the league of 22.9.The Bills rank 25th in the NFL with 28.3 points per game allowed on defense over the previous three contests, but they’ve really been thriving on offense, as they rank fourth-best with 32.3 points per game during that stretch.Eagles scoring insightsAt home, the Eagles’ scoring average is 24.9 points per game, which is higher than their average on the road (21.9).On defense, Philadelphia allows fewer points at home (17.1 per game) than on the road (21.1).Offensively, the Eagles are scoring 25.8 points per game in divisional matchups, which is better than their 22.0 average outside the division.Philadelphia has allowed 23.2 points per game in the division, which is higher than its mark against the rest of the league of 17.3.The Eagles are putting up 26.3 points per game in their past three games (10th in league), and giving up 13.3 (best).Bills injury reportBills:
Jordan Poyer: Did Not Participate In Practice (Hamstring),
Jordan Phillips: Did Not Participate In Practice (Ankle),
Cameron Lewis: Limited Participation in Practice (Hamstring),
Taron Johnson: Limited Participation in Practice (Quad),
Dawson Knox: Did Not Participate In Practice (Knee),
Dalton Kincaid: Did Not Participate In Practice (Knee),
DaQuan Jones: Did Not Participate In Practice (Calf),
Ray Davis: Full Participation in Practice (Knee),
Joey Bosa: Limited Participation in Practice (Hamstring),
Cole Bishop: Full Participation in Practice (Ribs),
Josh Allen: Limited Participation in Practice (Foot),
Shaq Thompson: Limited Participation in Practice (Neck),
Matt Prater: Did Not Participate In Practice (Quad)Eagles injury reportEagles:
Cameron Williams: Full Participation in Practice (Shoulder),
DeVonta Smith: Full Participation in Practice (Illness),
Cameron Latu: Full Participation in Practice (Stinger),
Lane Johnson: Did Not Participate In Practice (Foot),
Fred Johnson: Full Participation in Practice (Calf),
Landon Dickerson: Did Not Participate In Practice (Illness),
Nakobe Dean: Did Not Participate In Practice (Hamstring),
Jalen Carter: Full Participation in Practice (Shoulders),
Jihaad Campbell: Full Participation in Practice (Back),
A.J. Brown: Did Not Participate In Practice (Tooth),
Zack Baun: Full Participation in Practice (Hand)
Watch Buffalo Bills vs. Philadelphia Eagles on Fubo! (Regional restrictions may apply)