The New Orleans Saints (5-10) and Tennessee Titans (3-12) meet Sunday in a Week 17 matchup at Nissan Stadium in Nashville, Tennessee. Kickoff is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Saints vs. Titans odds and make our expert NFL picks and predictions for the best bets.

The Titans lead the all-time series 9-7-1, although the Saints won 16-15 in New Orleans in the most recent meeting on Sept. 10, 2023. Tennessee’s last win in the series was 23-21 at home on Nov. 14, 2021.

The Saints won 29-6 against the New York Jets in Week 16 as a 7-point favorite as the Under (40) cashed. Rookie QB Tyler Shough threw for 308 yards and a TD while WR Chris Olave went for 10 receptions for 148 yards and 2 TDs. New Orleans has won 3 in a row and has covered in each of its past 4 games. The Under is 9-1-1 in the Saints’ past 11 games.

New Orleans is 1-3 straight up (SU) against the AFC this season but is 3-1 ATS in those games, while the Under is 3-1 in those games.

The Titans belted the Kansas City Chiefs 26-9 in Week 16 in Nashville as a 3.5-point underdog as the Under (37.5) cashed. Rookie QB Cam Ward threw for 228 yards and a 2 TDs while RB Tony Pollard rushed for 102 yards, his third straight 100-yard game. TE Chig Okonkwo posted 6 grabs for 44 yards and a TD, WR Chimere Dike had 40 yards and a TD, and RB Tyjae Spears rushed for 52 yards and a score

Tennessee has won 2 of its past 3 games while also going 2-1 ATS in those games. The Titans are 5-2 ATS in their past 7 games, too, while the Over is 6-3 in their past 9 outings. The Titans are 1-3 vs. NFC this season, going 2-2 ATS in those games, while the Over is 4-0 in those games.

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Saints at Titans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 5:21 p.m. ET.

Moneyline (ML): Saints -145 (bet $145 to win $100) | Titans +120 (bet $100 to win $120)Against the spread: Saints -2.5 (-110) | Titans +2.5 (-110)Over/Under (O/U): 39.5 (O: -110 | U: -110)Saints at Titans key injuries

Saints

DT Bryan Bresee (knee) outRB Alvin Kamara (knee, ankle) outWR Chris Olave (back) questionableOG Cesar Ruiz (ankle) outPK Charlie Smyth (illness) questionable

Titans

CB Marcus Harris (knee) outLB Oluwafemi Oladejo (fibula) outSaints at Titans picks and predictionsPrediction

Saints 21, Titans 18

The SAINTS (-145) have been red hot lately (though both of these teams are playing their best football of the season in December). Things are looking up for both teams heading into the offseason, especially with both currently slotted in the top 10 of the 2026 NFL Draft to give these teams an added boost.

The Saints have won 3 in a row while the Titans have won 2 of the past 3 outings. While the records aren’t impressive, this could be one of the better games of Week 17.

The SAINTS -2.5 (-110) are the lean but go with a half-unit play at most.

New Orleans has covered in 4 in a row and is 5-1 ATS in its past 6 games. Tennessee is 2-1 ATS in the past 3 and 5-2 over its previous 7 games. Don’t get crazy on New Orleans as the Saints are middle of the road against the run, allowing 1,893 rushing yards and 4.1 yards per carry (YPC). Pollard has 3 straight 100-yard games and if anybody on the Titans is going to ruin your bet, it’s him.

UNDER 39.5 (-110) is also worth playing lighting, with a half-unit bet at best.

While the Under is 3-1 in the past 4 home games for the Titans, the Over is 4-0 in 4 games against the NFC this season, so be careful.

The Under is 9-1-1 in the past 11 games for the Saints and that’s an awfully strong trend — and evidence we’ll get another low total.

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