San Francisco (11-4) brings a five-game winning streak into a matchup with Chicago (11-4) on Sunday, December 28, 2025 at Levi’s Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 3 points. The over/under for the outing is 52.5 points.
Facing the Indianapolis Colts in their last game, the 49ers won 48-27.
The Niners’ Brock Purdy was 25-for-34 for 295 yards versus the Colts, with five TDs and one INT.
The Bears beat the Green Bay Packers, 22-16, in their last contest.
49ers vs Bears betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-3)Moneyline: San Francisco (-181), Chicago (+151)Total: 52.5 points49ers betting insightsAt home this year, San Francisco is 4-2 overall and 3-3 against the spread.The 49ers have gone 10-5-0 against the spread this season.San Francisco has two wins ATS (2-1) as 3-point favorites or greater at home.In games they have played as 3-point favorites or more, the 49ers have an ATS record of 6-1.In six games at home this year, San Francisco has hit the over three times.This season, nine 49ers games have gone over the point total.49ers leadersPurdy: 1,737 PASS YDS / 248.1 YPG / 68.8% / 17 TD / 8 INT / 25 CAR / 98 RUSH YDS / 1 TDChristian McCaffrey: 280 CAR / 1,039 YDS / 69.3 YPG / 9 TD / 92 REC / 849 YDS / 56.6 YPG / 7 TDBrian Robinson Jr.: 86 CAR / 369 YDS / 24.6 YPG / 2 TD / 7 REC / 19 YDS / 1.3 YPG / 0 TDGeorge Kittle: 52 REC / 599 YDS / 59.9 YPG / 7 TDJauan Jennings: 49 REC / 566 YDS / 43.5 YPG / 8 TD49ers vs Bears game infoDate: Sunday, December 28, 2025Time: 8:20 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: NBC/PeacockLive stream: Watch on Fubo (Regional restrictions may apply)
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