The Seattle Seahawks (12-3) and Carolina Panthers (8-7) meet Sunday in a Week 17 matchup at Bank of America Stadium in Charlotte, North Carolina. Kickoff is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Seahawks vs. Panthers odds and make our expert NFL picks and predictions for the best bets.

The Seahawks lead all-time series 11-5, including a 37-27 win in the most recent meeting Sept. 24, 2023. Seattle has won 4 of the past 5 meetings dating back to Dec. 4, 2016.

The Seahawks won 38-37 in OT in a wild Thursday night game against the Los Angeles Rams in Week 16, failing to cover as a 2-point home favorite while the Over (42) hit with ease. QB Sam Darnold threw for 270 yards and 2 TDs, while RB Kenneth Walker III rushed for 100 yards and a TD. WR Jaxon Smith-Njigba went for 8 grabs, 96 yards and a score.

The Seahawks have won 5 in a row but are 2-3 against the spread (ATS) in the win streak while alternating the Over and Under in the past 7 games. Seattle has a 1-game lead over the LA Rams and San Francisco 49ers for first place in the NFC West, and they’re up 1 game on the Chicago Bears for the top spot in the NFC, too.

The Panthers have a 1-game lead in the NFC South over the Tampa Bay Buccaneers with 2 games left. Carolina topped Tampa Bay 23-20 as a 3-point home underdog in Week 16 as the Under (44) held on. QB Bryce Young threw for 191 yards and 2 TDs, hooking up once with rookie WR Tetairoa McMillan for a score. T-Mac finished with 6 receptions for 73 yards.

Carolina has alternated wins and losses in each of the past 9 games dating back to Week 7. It has alternated covers and non-covers in the same 9-game span, too. The Under is 3-1 in the Panthers’ past 4 games and 5-2 in their previous 7 outings.

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Seahawks at Panthers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:47 p.m. ET.

Moneyline (ML): Seahawks -350 (bet $350 to win $100) | Panthers +280 (bet $100 to win $280)Against the spread: Seahawks -7 (-115) | Panthers +7 (-105)Over/Under (O/U): 42.5 (O: -110 | U: -110)Seahawks at Panthers key injuries

Seahawks

S Coby Bryant (knee) outOT Charles Cross (hamstring) out

Panthers

G Robert Hunt (biceps) outWR David Moore (elbow) outLB Trevin Wallace (shoulder) outDT Tershawn Wharton (hamstring) outSeahawks at Panthers picks and predictionsPrediction

Seahawks 25, Panthers 16

The Seahawks (-350) will cost you 3 1/2 times your potential return, and that’s quite a bit of risk for not nearly enough reward. Seattle is playing for a division title, a first-round bye and home-field advantage to the Super Bowl. But the Panthers are vying for a division title and playoff spot, as well (though even with a loss, they can still get in next week).

Carolina faces an uphill battle, and it’s not going to end well for the home side.

PASS.

The SEAHAWKS -7 (-115) are laying the big points on the road. The Seattle defense is going to make it very hard on home side, and Young can be easily coaxed into miscues. Don’t be surprised if the Seahawks defense gets a score.

The Panthers are 2-1 ATS in their last 3 games as an underdog of 7 or more points, including outright wins against the LA Rams at home (31-28 in Week 13) as a 10.5-point underdog, and at Green Bay (16-13 in Week 9) as a 13.5-point dog. So, be careful.

UNDER 42.5 (-110) is the lean, with a half-unit bet at best.

The Under has cashed in 2 in a row for Carolina, and in 5 of the Panther’s past 7 outings. The Under is 3-3 in the past 6 games for Seattle, which has allowed 16 or fewer points in 3 of the past 4 outings. Go low but, again, be careful.

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