Jacksonville (11-4) brings a six-game winning streak into a matchup with Indianapolis (8-7) on Sunday, December 28, 2025 at Lucas Oil Stadium. The Jaguars are the favorites in this one, with the spread sitting at 5.5 points. An over/under of 48.5 points has been set for the contest.
In their last game, the Jaguars won against the Denver Broncos, 34-20.
Jags quarterback Trevor Lawrence was 23-for-36 for 279 yards, with three TDs and no INTs, against the Broncos.
In their most recent contest, the Colts lost versus the San Francisco 49ers, 48-27.
Jaguars vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 1:39 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Jacksonville (-5.5)Moneyline: Jacksonville (-258), Indianapolis (+209)Total: 48.5 pointsJaguars betting insightsOn the road, Jacksonville is 5-2 overall and 4-3 against the spread.The Jaguars have put together a 10-5-0 record against the spread this season.Jacksonville is unbeaten ATS (1-0) as 5.5-point favorites or more on the road.The Jaguars are a perfect 2-0 ATS when playing as at least 5.5-point favorites.This year, in seven away games, Jacksonville has gone over the total six times.Jaguars games have gone over the total nine times this season.Jaguars leadersLawrence: 3,489 PASS YDS / 232.6 YPG / 60% / 26 TD / 11 INT / 72 CAR / 322 RUSH YDS / 7 TDTravis Etienne: 229 CAR / 999 YDS / 66.6 YPG / 7 TD / 33 REC / 270 YDS / 18.0 YPG / 6 TDJakobi Meyers: 64 REC / 752 YDS / 53.7 YPG / 3 TDParker Washington: 45 REC / 645 YDS / 46.1 YPG / 4 TDBrian Thomas: 41 REC / 619 YDS / 51.6 YPG / 2 TDJaguars vs Colts game infoDate: Sunday, December 28, 2025Time: 1 p.m. ETCity: Indianapolis, IndianaVenue: Lucas Oil StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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