Data Skrive
Having taken six in a row, the Jacksonville Jaguars (11-4) will play the Indianapolis Colts (8-7). The Jaguars are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5). The predicted point total for the matchup is 48.5.
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Jaguars vs. Colts Odds & Betting Lines
Jaguars vs Colts Betting Information updated as of December 27, 2025, 8:33 a.m. ET.
Favorite
Spread
Favorite Spread Odds
Underdog Spread Odds
Total
Over Total Odds
Under Total Odds
Jaguars
-5.5
-115
-105
48.5
-110
-110
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Jaguars vs. Colts Prediction & PickPick ATS: Colts (+5.5)
Pick OU: Over (48.5)
Prediction:
Jaguars 27 – Colts 23
How to Watch Jacksonville vs. IndianapolisGame date: Sunday, December 28, 2025Time: 1 p.m. ETVenue: Lucas Oil StadiumLocation: Indianapolis, IndianaTV: Watch on FOXStreaming: FOX One (Limited time offer: 50% off the first two months)Jaguars vs. Colts Recent MatchupsIn their past five head-to-head contests, Jacksonville has won against Indianapolis four times.Over their last five head-to-head contests, Jacksonville has scored 164 points, while Indianapolis has posted 120.Jacksonville Betting InfoJacksonville has 10 wins in 15 games versus the spread this year.The Jaguars have been favored by 5.5 points or more two times this season, and covered the spread in both.Jacksonville games this year have gone over the total in nine out of 15 opportunities (60%).When playing as moneyline favorites, the Jaguars are 6-1 (winning 85.7% of the time).The Jaguars have an implied win probability, based on the moneyline, of 72.1%.Jaguars Stats
Stat
Average (Total)
Rank
Pass yards
218.3 (3,275)
16
Rush yards
118.1 (1,771)
19
Points scored
27.3 (410)
7
Pass yards against
230.3 (3,455)
25
Rush yards against
87.3 (1,309)
1
Points allowed
20.8 (312)
10
Jacksonville’s Key PlayersOffenseTrevor Lawrence has passed for 3,489 yards (ninth in the NFL), 26 touchdowns (fourth in the NFL) and 11 interceptions this year. He is averaging 232.6 yards per game and 7.1 per attempt, while completing 60% of his attempts.He has added 322 rushing yards (21.5 per game) and seven touchdowns on the ground.Travis Etienne averages 4.4 yards per carry (23rd in the NFL) and 66.6 yards per game, and has 999 total rushing yards. He has recorded seven rushing TDs this season.Etienne has 33 catches on 48 targets for 270 yards. He has six receiving TDs.In the passing attack, Parker Washington, has contributed with 645 receiving yards and four touchdowns after pulling down 45 balls on 76 targets. Per game, he’s averaging 46.1 yards and 3.2 receptions through 14 games.Jakobi Meyers has 64 receptions for 752 yards and three touchdowns. He’s been targeted 95 times in the air attack, and averages 4.6 receptions and 53.7 yards in 14 games played.DefenseOn defense, Foyesade Oluokun has one sack to go with five TFL, 122 tackles, and one interception in 2025.Devin Lloyd has 65 tackles, five TFL, 1.5 sacks, and five interceptions this season. He’s third on the Jaguars in tackles.Josh Hines-Allen has collected 41 tackles, 11 TFL, seven sacks, and two passes defended.This season, Andrew Wingard has 79 tackles, two TFL, and one interception. He’s second on the Jaguars in tackles.Indianapolis Betting InfoIndianapolis is 8-7-0 against the spread this year.This season, the Colts won ATS in their only game as an underdog of 5.5 points or more.Indianapolis’ games have finished with a final combined score above the over/under eight times this season.This season, the Colts have won two out of the six games in which they’ve been the underdog.The moneyline for this contest implies a 32.3% chance of a victory for the Colts.Colts Stats
Stat
Average (Total)
Rank
Pass yards
230.7 (3,460)
9
Rush yards
124.1 (1,862)
10
Points scored
27.9 (419)
6
Pass yards against
250.7 (3,761)
31
Rush yards against
98.5 (1,477)
5
Points allowed
23.4 (351)
18
Indianapolis’ Key PlayersOffenseJonathan Taylor averages 99.3 rushing yards per game this year (1,489 total yards to rank second in the NFL), while scoring 17 rushing touchdowns.On top of his impact on the ground, Taylor has caught 41 passes (on 47 targets) for 351 yards (fifth on the Colts), with two receiving touchdowns. He’s averaging 23.4 yards per game.Michael Pittman Jr. has 757 receiving yards and seven touchdowns on 76 receptions, while being targeted 104 times.In 13 games played this season, Alec Pierce has 43 catches (3.3 receptions per game on 5.5 targets per game) for 871 yards and four receiving touchdowns.Tyler Warren has 66 catches for 748 yards and four receiving touchdowns. He averages 4.4 yards per game through 15 games and has been targeted 99 times.DefenseGermaine Pratt’s 2025 output includes 114 tackles and six TFL through 14 games. He leads the Colts in tackles.Nick Cross has one interception on top of 101 tackles, four TFL, 2.5 sacks, and five passes defended.Zaire Franklin has recorded two sacks as well as five TFL and 108 tackles in the 2025 season.Laiatu Latu has intercepted three passes to go with 41 tackles, 11 TFL, 7.5 sacks, and four passes defended.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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