The Buffalo Bills are turning to the final page of their 2025 regular season against the New York Jets.

Following an offseason that has built Super Bowl hopes, can the Bills turn their fortunes in the right direction and make that a reality after a bumpy year?

Before we even get to the team’s next kickoff, there will be a lot of Bills-related discussions and conversations to be had throughout the coming days.

With that, here are five storylines to watch for during the lead up to Bills (11-5) against the Jets (3-13) in Week 18 at Highmark Stadium:

‘The Ralph’s’ finale’

The huge talking point already this week is this contest being the last regular season game at the Bills’ current home. The new Highmark Stadium opens in 2026.

Memories and leaving with a win will be discussed all week since the postseason may not provide another home game in the coming weeks.

Josh’s health

Bills quarterback Josh Allen is not often injured but his foot issue appeared to hamper him in Buffalo’s loss to the Philadelphia Eagles last week. As the franchise player, Allen’s health will have eyes all over it before the postseason.

Seeding

While there may not be a home game for the Bills upcoming in the postseason, a better seed could change that. The Bills are currently at No. 7. Buffalo can still move up in seeding. The Bills can reach as high as the No. 5 seed with a win and depending on outcomes elsewhere in the AFC.

Here’s where the rest of the AFC shakes out ahead of Week 18:

Denver Broncos (13-3)New England Patriots (13-3)Jacksonville Jaguars (12-4)Pittsburgh Steelers (9-7)Houston Texans (11-5)Los Angeles Chargers (11-5)Buffalo Bills (11-5)Other starters

Likewise to Allen, there are other injured players on the Bills roster that could stand to use a rest. In addition, those not hurt could avoid injury by not playing.

What do the Bills decide to do in terms of starters in their finale at Highmark Stadium? There is plenty of head coach Sean McDermott to consider.

Cook’s numbers

One pretty huge milestone to watch (and consider in terms of a starter playing) relates to running back James Cook. He has the most rushing yards among NFL running backs in 2025 with 1,606.

How much playing time should he get to keep his potential rushing title? Cook currently leads it by 47 yards over the Indianapolis Colts‘ Jonathan Taylor.