Texans vs. Colts prediction, pick, odds for Sunday's NFL Week 18 game

Texans vs. Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:16 a.m.

Moneyline (ML): Houston -625 (Bet $625 to win $100) | Indianapolis +450 (Bet $100 to win $450)Against the spread (ATS): Houston -10.5 (-110) | Indianapolis +10.5 (-110)Over/Under (O/U): 39 (O: -110 | U: -110)Texans vs. Colts betting tips preview

The Houston Texans (11-5) host the Indianapolis Colts (8-8) on Sunday, January 4, 2026 at NRG Stadium and will aim to continue an eight-game winning streak. Check out the best bets.

The Texans last took to the field against the Los Angeles Chargers, and they came out on top 20-16. The Colts fell short in their last outing by a final score of 23-17 against the Jaguars. In that last outing for the Texans, C.J. Stroud completed 16 of 28 passing attempts (57.1%) and totaled 244 yards through the air, connecting on two touchdown passes but giving away two interceptions. Woody Marks had 19 rushing attempts and finished with 71 yards. Jayden Higgins found paydirt once, and ended the contest with two catches for 88 yards.

For the Colts in their last game, Philip Rivers completed 17 of 30 passing attempts (56.7%) and totaled 147 yards through the air, connecting on one touchdown pass but giving away one interception. Jonathan Taylor had 21 rushing attempts and finished with 70 yards and one touchdown. Tyler Warren ended the contest with five catches for 43 yards.

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Texans vs. Colts key injuriesTexansLB Azeez Al-Shaair (knee) limited participation in practiceDE Denico Autry (knee) limited participation in practiceLS Austin Brinkman (knee) full participation in practiceOT Trent Brown (ankle) limited participation in practiceCB Ajani Carter (hamstring) full participation in practiceWR Nico Collins (NIR – Rest) limited participation in practiceOT Aireontae Ersery (thumb) full participation in practiceK Ka’imi Fairbairn (illness) limited participation in practiceLB Jamal Hill (calf) did not participate in practiceOG Ed Ingram (ankle) limited participation in practiceCB Kamari Lassiter (ankle) did not participate in practiceDT Sheldon Rankins (elbow) limited participation in practiceTE Dalton Schultz (NIR – Personal) did not participate in practiceCB Derek Stingley Jr. (oblique) limited participation in practiceDE Darrell Taylor (ankle) full participation in practiceColtsCB Mekhi Blackmon (back) full participation in practiceC Tanor Bortolini (concussion) full participation in practiceLB Zaire Franklin (illness) did not participate in practiceCB Sauce Gardner (calf) did not participate in practiceCB Jaylon Jones (illness) full participation in practiceTE Will Mallory (lung) did not participate in practiceC Danny Pinter (rib) full participation in practiceOT Bernhard Raimann (elbow) full participation in practiceQB Anthony Richardson (eye) full participation in practiceS Daniel Scott (knee) full participation in practiceOG Dalton Tucker (shoulder) full participation in practiceDE J.T. Tuimoloau (oblique) full participation in practiceTexans vs. Colts prediction

Texans 28, Colts 17

Moneyline pick: Texans -625Based on this contest’s moneyline, the Texans have an implied win probability of 86.2%.Houston has gone 6-2 in games they were listed as the moneyline favorite (winning 75% of those games).The Texans have played as a moneyline favorite of -625 or shorter in only one game this season, which they won.This season, Indianapolis has been the underdog seven times and won two of those games.The Colts have played as an underdog of +450 or more once this season and lost that game.Pick ATS: Colts (+10.5)Houston has posted a 9-7-0 record against the spread this season.The Texans have been favored by 10.5 points or more two times this season and covered the spread in one of them.Indianapolis has eight wins against the spread in 16 games this season.The Colts have been underdogs by 10.5 points or more once this season and covered the spread.Pick OU: Over (39)The Texans and their opponents have scored more than 39 points in eight of 16 games this season.The Colts have combined with their opponent to score more than 39 points in 14 of 16 games this season.The two teams average 50.2 points per game combined, 11.2 more points than this game’s total.Opponents of these two teams score 40 combined points per game, one more point than this matchup’s over/under.

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Texans vs. Colts prediction, pick, odds for Sunday’s NFL Week 18 game

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