Eagles vs. 49ers spread, line, over/under

NFL Wild Card Round odds: Eagles vs. 49ers spread, line, over/under

The Philadelphia Eagles are 5.5-point favorites as they head into a showdown with the San Francisco 49ers in the NFC Wild Card round of the 2025 NFL Playoffs on January 11, 2026 at 4:30 p.m. ET on FOX.

Eagles vs. 49ers game infoGame day: Sunday, January 11, 2026Game time: 4:30 p.m. ETTV channel: FOXLocation: Philadelphia, PennsylvaniaStadium: Lincoln Financial FieldLive stream: Watch this game on Fubo (Regional restrictions may apply)Watch Philadelphia Eagles vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)Eagles vs. 49ers odds & betting linesSpread favorite: Philadelphia (-5.5)Moneyline: Philadelphia (-241), San Francisco (+199)Total: 44.5 pointsExpert NFL picks: Exclusive betting insights only at USA TODAY.

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:56 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Eagles vs. 49ers recent matchupsSan Francisco and Philadelphia have split their past four matchups (2-2).Philadelphia outscored San Francisco 94-76 in those four head-to-head matchups.Eagles vs. 49ers betting insightsPhiladelphia has 10 wins against the spread through 17 opportunities so far this season (10-7-0). In 15 games as a moneyline favorite, the Eagles have gone 9-6. San Francisco, in 17 games with a set spread so far this season, has gone 11-6-0 against the spread. The 49ers’ record in games they’ve played as the underdog this year is 1-4.Eagles scoring insightsThe Eagles’ scoring average at home, 23.9 points per game, is higher than their average away, 20.9.On defense, Philadelphia allows fewer points at home (18.0 per game) than away (20.1).The Eagles average more points in division games (24.3) than against the rest of the league (21.2).Philadelphia is allowing 23.3 points per game in divisional contests, which is higher than its 16.8 average outside the division.With an average of 19.7 points per game on offense and 18.0 points allowed on defense over the last three games, the Eagles rank 18th and 10th, respectively, during that period.49ers scoring insightsAt home, the 49ers’ scoring average is 23.1 points per game, which is worse than their average on the road (28.0).Defensively, San Francisco’s average at home, 22.1 points conceded, is a tad worse than its average away, 21.6.Offensively, the 49ers average fewer points in division games (21.5) than outside the division (28.0).San Francisco has conceded 21.3 points per game in the division, which is a little lower than its average outside the division of 22.1.In their past three games, the 49ers are putting up 31.0 points per game (fifth-best in league), and giving up 26.0 (23rd).Eagles injury reportEagles: Jaelan Phillips: Full Participation in Practice (Ankle), Azeez Ojulari: Full Participation in Practice (Hamstring), Lane Johnson: Limited Participation in Practice (Foot), Dallas Goedert: Limited Participation in Practice (Knee), Marcus Epps: Full Participation in Practice (Concussion), Nakobe Dean: Full Participation in Practice (Hamstring), Jalen Carter: Limited Participation in Practice (Hip), Brett Toth: Did Not Participate In Practice (Concussion), Grant Calcaterra: Limited Participation in Practice (Ankle), Landon Dickerson: Did Not Participate In Practice (Rest)49ers injury report49ers: Dee Winters: Did Not Participate In Practice (Ankle), Trent Williams: Limited Participation in Practice (Hamstring), Keion White: Did Not Participate In Practice (Groin), Ricky Pearsall: Did Not Participate In Practice (Knee), Christian McCaffrey: Full Participation in Practice (NIR – Rest), George Kittle: Limited Participation in Practice (Ankle), Yetur Gross-Matos: Limited Participation in Practice (Knee), Luke Gifford: Did Not Participate In Practice (Quadricep), Jordan Elliott: Limited Participation in Practice (Knee), Kalia Davis: Full Participation in Practice (Knee), Jacob Cowing: Full Participation in Practice (Hamstring), Ji’Ayir Brown: Full Participation in Practice (Rib)Watch Philadelphia Eagles vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

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