Jan. 16, 2026, 5:47 p.m. PT

Indianapolis Colts defensive end Kwity Paye (51) tackles San Francisco 49ers running back Christian McCaffrey (23) on Monday, Dec. 22, 2025, during a game at Lucas Oil Stadium in Indianapolis.

The Seattle Seahawks are strong favorites (-7) in this year’s Divisional Round of the NFC playoffs, where they will meet the San Francisco 49ers. The game begins at 8 p.m. ET on FOX from Lumen Field in Seattle, Washington. The over/under is 45 in the contest.

In their last game, the 49ers won against the Philadelphia Eagles, 23-19.

Against the Eagles, Brock Purdy completed 18 of 31 passes for 262 yards, with two touchdowns and two interceptions, for the Niners.

The Seahawks will be facing the 49ers for the second time in a row, with the Seattle Seahawks taking the previous matchup on January 3, 2026, .

49ers vs Seahawks betting information

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 8:48 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Expert NFL picks: Exclusive betting insights only at USA TODAY.Spread favorite: Seattle (-7)Moneyline: Seattle (-334), San Francisco (+267)Total: 45 points49ers betting insightsSan Francisco is 7-2 overall, and 7-2 against the spread, in away games.The 49ers covered the spread 11 times in 17 games during the regular season, and are 1-0-0 ATS in the postseason.San Francisco is unbeaten ATS (1-0) as 7-point underdogs or more away from home.The 49ers have covered every time (1-0) as 7-point underdogs or greater in the regular season and playoffs.San Francisco has gone over the total in six of nine away games this season.The 49ers had 10 of their 17 games go over the point total in the regular season, and zero of one in the playoffs.49ers leadersPurdy: 2,167 PASS YDS / 240.8 YPG / 69.4% / 20 TD / 10 INT / 33 CAR / 147 RUSH YDS / 3 TDChristian McCaffrey: 311 CAR / 1,202 YDS / 70.7 YPG / 10 TD / 102 REC / 924 YDS / 54.4 YPG / 7 TDBrian Robinson Jr.: 92 CAR / 400 YDS / 23.5 YPG / 2 TD / 8 REC / 25 YDS / 1.5 YPG / 0 TDJauan Jennings: 55 REC / 643 YDS / 42.9 YPG / 9 TDKendrick Bourne: 37 REC / 551 YDS / 39.4 YPG / 0 TD49ers vs Seahawks game infoDate: Saturday, January 17, 2026Time: 8 p.m. ETCity: Seattle, WashingtonVenue: Lumen FieldTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch Seattle Seahawks vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

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