April 4, 2026, 8:00 a.m. PT

It’s hard to make top-to-bottom upgrades in the draft, but the San Francisco 49ers have the opportunity to do so with all six of their picks in the first 140 selections, including four picks in the fourth round.

The 49ers don’t pick until No. 27 overall in the first round, but they can still add some top talent at positions of need throughout all three days of the draft.

NFL.com’s Chad Reuter went through the first five rounds in his new draft and focused almost exclusively on the trenches and the secondary for San Francisco. He selected three trench players (two on the offensive line and one of the defensive line) and two defensive backs. The only other position Reuter drafted was receiver.

Here is the latest five-round mock draft for the 49ers from NFL.com:

Round 1, Pick No. 27: Arizona State OT Max IheanachorRound 2, Pick No. 59: Texas CB Malik MuhammadRound 4, Pick No. 127: Alabama EDGE LT OvertonRound 4, Pick No. 133: Georgia WR Dillon BellRound 4, Pick No. 138: Boston College OT Jude BowryRound 4, Pick No. 139: Kansas State S VJ PayneExpert NFL picks: Exclusive betting insights only at USA TODAY.

Iheanachor makes a lot of sense at No. 27 because of how depleted the 49ers’ offensive line gets if injuries hit them hard or if Trent Williams leaves. The Arizona State product gives San Francisco a stable floor no matter what happens. While Iheanachor is a right tackle, Bowry plays on the left side, so the 49ers would have two solid players on either side of the offensive line.

Muhammad was a solid ballhawk for the Longhorns in 2025 with two interceptions and four defended passes, and he finished with three interceptions and 16 defended passes in three seasons. Adding Payne with the final pick gives the 49ers even more depth in the secondary after the K-State product added four interceptions and 10 defended passes in the past three seasons.

Overton is a player some have mocked to the 49ers in the first round, so getting him late in the second would be a coup. The Alabama product had four sacks and 42 tackles this past season with seven sacks, 132 tackles and 12 tackles for a loss in four college seasons.

Bell is the only skill position player drafted in this mock, which would mean the 49ers feel confident in Mike Evans, Christian Kirk, Ricky Pearsall, Demarcus Robinson and Jacob Cowing. Bell caught just 27 passes for 268 yards and two scores in 2025, but his 6-foot-1 and 209-pound frame is built more for a Deebo Samuel-type role than as a pure receiver threat. He caught 119 balls for 1,269 yards and 11 touchdowns with 51 rushes for 373 yards and five rushing scores in four years at Georgia.