Despite an impressive come-from-behind win against the New England Patriots, Seattle fans likely left their Week 1 win feeling a bit deflated.

Unfortunately, just five plays into the season, quarterback Sam Darnold suffered a hip injury that puts his availability for Week 2, and potentially several more weeks, in doubt.

The good news: Seattle’s defense held an improved Patriots offense to just 10 points and forced Drake Maye into three interceptions.

Still, the market has responded fairly drastically to Darnold’s injury.

Can the Seahawks build on their late-game success versus New England to secure a Week 2 road win against Arizona?

Check out our first-look Seahawks-Cardinals preview below, featuring expert model predictions, best bets, and more, to find out.

Seahawks vs. Cardinals Game Info:

Seattle heads to State Farm Stadium on Sunday, September 20, for an NFC West matchup against Arizona in Week 2.

The Seahawks and Cardinals know each other well as division rivals, and this early-season meeting gives both teams an opportunity to make an immediate move inside the NFC West.

Seattle enters as the road favorite, while Arizona gets the matchup at home with kickoff scheduled for 4:25 p.m. ET.

Here are the key game details:

GameDetailsMatchupSeattle Seahawks vs. Arizona CardinalsDateSunday, September 20, 2026Kickoff4:25 p.m. ETVenueState Farm StadiumDimers PredictionSeahawks 27, Cardinals 18Best Available Odds: Seahawks vs. Cardinals

Below, we have listed out the best sportsbook odds for every popular market alongside the updated Dimers model probabilities.

MarketSelectionBest Odds/SportsbookImplied ProbabilityMoneylineSeattle Seahawks-530 at BetRivers79.1%MoneylineArizona Cardinals+410 at DraftKings20.9%SpreadSeattle -10-106 at Caesars Sportsbook48.7%SpreadArizona +10-110 at BetRivers51.3%TotalOver 44.5-109 at BetRivers51.1%TotalUnder 44.5-110 at DraftKings48.9%

Seattle is clearly the more likely winner according to the model, with Dimers assigning the Seahawks a 79.1% win probability.

However, laying double digits is a different question.

Dimers gives Arizona +10 a 51.3% probability compared with 48.7% for Seattle -10.

The projected 27-18 final score would also leave the Cardinals covering the current 10-point spread by one point.

The total is even tighter. Dimers gives Over 44.5 a 51.1% probability and Under 44.5 a 48.9% chance, while the projected score lands at 45 combined points.

Best Early Value: Cardinals Moneyline (+410)

The most interesting price in the current market may actually be on the heavy underdog.

Dimers gives Arizona a 20.9% chance of winning outright and specifically lists the Cardinals moneyline at +410 as carrying a 1.3% edge.

MoneylineDimers ProbabilityBest Odds AvailableDimers EdgeArizona Cardinals to win20.9%+410 at DraftKings+1.3%Seahawks vs. Cardinals Prediction:

Ultimately, the first-look simulations from Dimers indicate that Seattle will control the matchup without necessarily running away from Arizona.

The Seahawks carry a 79.1% win probability and are projected to win 27-18, but Arizona +10 receives the slightly stronger spread probability at 51.3%.

The Cardinals moneyline is the more aggressive position.

Arizona is projected to win only 20.9% of the time, but the available +410 price gives it a 1.3% edge via the Dimers model.

Dimers prediction: Seahawks 27, Cardinals 18Seattle win probability: 79.1%Arizona win probability: 20.9%Best early value: Cardinals moneyline +410 at DraftKingsSpread lean: Cardinals +10Total lean: Over 44.5Prediction Markets for Seahawks vs. Cardinals:

Local Seahawks and Cardinals fans in both Washington and Arizona can now use prediction markets to trade on the NFL as an alternative to typical betting. Here are our top options, and available promo codes for new users:

PlatformNFL/MLB Eligible?September ’26 Sign-Up BonusVerified Promo CodesPolymarketYes$50CUSE
,
MASS
,
OREGON
,
SILIVE
,
CLEVEKalshiYes$25SYRACUSE
,
OREGONLIVE1
,
MASSLIVE1
,
SILIVE
, CLEVELANDNovigYes$50SYRACUSE
,
OREGON
,
MASSLIVE
, CLEVELANDNFL Sunday: Seahawks vs. Cardinals

We emphasize that all of the NFL best trades and NFL predictions in this preview are based on 10,000 data-driven simulations of the Seahawks vs. Cardinals, and they are correct at the time of publishing.

Learn more about our gaming editorial staff.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

If you purchase a product or register for an account through a link on our site, we may receive compensation. By using this site, you consent to our User Agreement and agree that your clicks, interactions, and personal information may be collected, recorded, and/or stored by us and social media and other third-party partners in accordance with our Privacy Policy.